Molecular and cellular characterization of Plasmodium berghei PPM9 phosphatase, an enzyme dispensable during both asexual and sexual life cycle stages

Protein phosphorylation is a key regulatory mechanism controlling many essential biological processes in Plasmodium berghei. While the parasite kinome has been extensively investigated, the phosphatome, particularly the metal-dependent PP2C phosphatases, remains poorly characterized. Among these enzymes, PPM9 has been proposed to play an important role in parasite development, although previous functional studies have produced conflicting conclusions regarding its essentiality.

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