WELCOME TO THE CENTER FOR INFECTION & IMMUNITY OF LILLE

Our team studies the interactions between cells and tissues on the one hand, and bacteria, toxins, antimicrobial peptides and viruses on the other hand, by focusing on the mechanical and biological response. During the interaction, structural modifications are mechanically induced, which in turn will modulate a cellular or even tissue response.
The response we are studying is linked to the autophagy mechanism, which allows the cell to degrade microbes that enter the cells, but some of these microbes have developed, during the course of evolution, systems to escape or even exploit it.
Depending on the mechanical properties of the cells, structurally, the fluidity, elasticity and viscosity are modified. This concerns molecules, membranes and intracellular compartments. All of this helps to define the response capacity to the interaction between the micro-organism and the cell or tissue.
This is why we are developing a multidisciplinary approach combining biology and physics and designing innovative methods that enable us to remove conceptual barriers with regard to these interactions between host and microbes. If we can control these interactions or the responses they cause, then we can modulate their consequences.
We propose 4 short videos which, after a quick introduction on the general problem, describe subjects currently studied in the Group:
1- Mechanobiology from the molecule to the cell and tissue
2- Innovative technologies in host-pathogen interactions
3- Health benefits of lactic acid bacteria in the gut
4- Cellular responses to norovirus infections.

Have a good viewing!