Post-Synthetic Functionalization of Porous Materials (MOFs and Silica) with Tetrapyrrole Macrocycles as Antiviral Materials against Coronaviruses and Hepatitis C Virus
Orfeas-Evangelos Plastiras, Peggy Bouquet*, Imelda Raczkiewicz*, Sandrine Belouzard*, Esther Martin De Fourchambault, Jeremy Dhainaut, Jean-Philippe Dacquin, Anne Goffard*, Christophe Volkringer
*U1019 − UMR 9017 − CIIL - Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, CNRS, INSERM, CHU de Lille, Lille 59000, France
Mesoporous silica SBA-15 and two Metal–Organic Frameworks (MOFs), UiO-66(Zr)-NH2 and MIL-125(Ti)-NH2, were functionalized with tetrapyrrole macrocycles (TpM), two chlorin, and two porphyrin molecules with a simple coupling reaction, creating a strong covalent amide bond. Next, their antiviral activity was assessed against HCoV-229E, two highly pathogenic coronaviruses, SARS-CoV-2 and MERS-CoV, and Hepatitis C virus (HCV) ...
