Functional study of two flexible regions of the hepatitis E virus ORF1 replicase.

Published: 03/16/2026

Mézière L , Fieulaine S, Montpellier C , Ferrié M, Tubiana T, Vanegas Arias G, Bressanelli S, Cocquerel L , Aliouat-Denis CM

AlphaFold2 models of HEV ORF1 polyprotein C-terminus and localization scheme of mutations and epitope tag insertions.

Hepatitis E virus (HEV), like other positive-sense RNA viruses, encodes a multidomain protein essential for replication, termed ORF1.

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