Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata
Published:
09/04/2026
Melnyk O, Caby S, Vigouroux A, Demanche C, Desmet R, Sénéchal M, Snella B, Mougel A, Boidin-Wichlacz C, Parmentier A, Pasco U, Cantel S, Moréra S, Vicogne J. Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata. Protein Sci. 2026 Sep;35(9):e70745. doi: 10.1002/pro.70745. PMID: 42554520; PMCID: PMC13440164.
Disulfide-rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80-residue proteins conserved across gastropods that form a long-standing orphan family whose structure and biological roles have remained unknown.
