Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach

Published: 01/30/2026

Valderrama, Katherine et al.

Journal of medicinal chemistry, 10.1021/acs.jmedchem.5c02409. 27 Jan. 2026, doi:10.1021/acs.jmedchem.5c02409

Pyridomycin is a natural product with potent activity against Mycobacterium tuberculosis (Mtb), acting through direct inhibition of the fatty acid synthesis enzyme InhA.
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