Metabolic adaptation of Yersinia pestis during flea colonization

Published: 06/01/2026

Bontemps-Gallo, Sébastien et al.

The FEBS journal, 10.1111/febs.70602. 26 May. 2026, doi:10.1111/febs.70602

Yersinia pestis, the causative agent of plague, has evolved a dual lifestyle enabling survival in both mammalian hosts and hematophagous flea vectors. While mammalian virulence has been extensively studied, the flea stage represents a highly selective and metabolically constraining environment that plays a decisive role in transmission.

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