CrpH of Bordetella pertussis, a prototypic PepSY_TM protein supporting heme-copper oxidoreductase function
Published:
04/07/2026
In the living world, copper is both toxic in excess and necessary for the activity of specific oxidoreductases and electron transfer chains and as such is involved in the host-pathogen interface.
Hachmi Majda & al
Mammalian hosts deploy anti-microbial strategies of copper intoxication or starvation of invading microorganisms, collectively called nutritional immunity, and bacteria have developed both protection and acquisition systems in response. We recently described a TonB-dependent copper importer, CrtABp in the whooping cough agent Bordetella pertussis. Here we characterized another protein encoded in the same operon and similarly upregulated by copper starvation, CrpH.
