Alpibectir-Ethionamide combination (AlpE) for the treatment of tuberculosis
Published:
04/13/2026
Edoo, Zainab & al - Nature communications - 10.1038/s41467-026-71460-6. 7 Apr. 2026, doi:10.1038/s41467-026-71460-6
Ethionamide (Eto) and prothionamide (Pto) are second-line antibiotics used for tuberculosis (TB) treatment. Both are prodrugs whose antibacterial activity depends on bioactivation by oxidases in Mycobacterium tuberculosis, including the Baeyer-Villiger monooxygenase MymA.
