A new family of TonB-dependent copper transporters linked to respiratory oxidase function

Published: 01/25/2026

Hachmi M, Mirgaux M, Wintjens R, Carassus C, Arnoux P, Roy G, Rivera-Millot A, Slupek S, Debrie A , Alaimo V, Billon G, Coutte L, Antoine R, Jacob-Dubuisson Jacob

 

The Journal of biological chemistry, 111180. 20 Jan. 2026. doi.org/10.1016/j.jbc.2026.111180

Copper is an essential metal notably found in respiration complexes for its redox properties. It is also toxic hence its cellular trafficking is tightly controlled. Bacteria have developed a number of defense systems against copper excess, but its acquisition pathways remain poorly characterized.

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