Dr. El Moukhtar Aliouat 
Professor of University of Lille

ORCID

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EDUCATION

  • 1995 : PhD in Life and Health Sciences - University of Science and Technology of Lille 1 (USTL).
  • 1996-1998 : Postdoctoral fellowship at GlaxoWellcome S.A. laboratories (Tres Cantos, Madrid, Spain) in the Microbiology department.
  • 1998 : Appointed Associate Professor in the Parasitology, Medical mycology, and Animal biology laboratory at the faculty of pharmacy of Lille (University of Lille 2).
  • 2001 : GRETA training course (Groupement d’Établissements publics approuvé par le Ministère de l’Agriculture et de la Forêt) to obtain Level 1 certification in animal experimentation (authorization n° 59-350070).
  • 2004: Habilitation to Supervise Research (HDR) – University of Lille 2 : Biology and cell cycle of Pneumocystis : epidemiological and pathophysiological impact.
  • 2006 : Appointed Professor, I took charge of the Parasitology, Medical mycology, and Animal Biology laboratory, which includes 4 Associate Professors and one Technician. I lead and coordinate all teaching activities and educational innovation projects.
  • 2015-2019 : Elected member of the Board of Directors and Vice-President of ANOFEL (Collège des enseignants de parasitologie et mycologie médicales).

 

POSITIONS HELD

  • Professor, department of Pharmacy (UFR3S) – University of Lille: Parasitology, Medical Mycology, and Animal biology laboratory.
  • Member (PI) of the API-B team since 2015, CIIL, Inserm U1019, CNRS UMR9017, University of Lille.

DISTINCTIONS / RESPONSIBILITIES

  • Professor, department of Pharmacy (UFR3S) – University of Lille: Parasitology, Medical Mycology, and Animal biology laboratory.
  • Member (PI) of the API-B team since 2015, CIIL, Inserm U1019, CNRS UMR9017, University of Lille.

 

Responsibilities :

Research :

  • Research activities on malaria: Discovery of new antimalarial molecules through molecular and functional characterization of phosphatases specific to Plasmodium falciparum.
  • Member of the « Action Coordonnée Paludisme » (IT I3M) and the "Therapies and Resistance" Working Group.
  • ORCID: orcid.org/0000-0003-2905-7126
  • Research-ID: D-2859-2018

Teaching :

  • Head of the Parasitology, Medical mycology, and Animal biology laboratory - department of pharmacy (UFR3S, University of Lille).
  • Since 2018: I have coordinated a national educational innovation project involving 18 faculties of pharmacy, 30 faculty members, and 1 instructional designer. Using the Opale/Scenari publishing platform, we have established a national database of Clinical Cases and Multiple-Choice Questions (MCQs) in Parasitology and Medical mycology for the pharmacy internat examination.

COMPETENCES / EXPERTISE

From 1991 to 2014: research projects on the biology of Pneumocystis spp. My research program focused on the interaction of Pneumocystis spp. with alveolar epithelial cells and on two other aspects of the pathophysiology of pneumocystosis (i) the host specificity of Pneumocystis sp. and (ii) the role of pulmonary surfactant in parasite development.

Since 2015: research project on the molecular and functional characterization of Plasmodium falciparum-specific phosphatases with the main objective of developing new antimalarial molecules.

Expertise :

  • Animal models of pneumocystosis in mice and rats
  • Endotracheal inoculation
  • P. berghei mouse model
  • Immunofluorescent staining and confocal analysis
  • Reverse genetics in P. falciparum (CrispR/Cas9, DICRE)
  • Culture of P. falciparum and generation of resistant mutants
  • Cytotoxicity on HFF and HepG2 cells
  • Pharmacokinetic study in mice
  • Recombinant protein production
  • Phosphatase activity analysis