Tropical Biome & Immuno-Pathophysiology


Head of team:

Sylviane PIED

Contact

Sylviane Pied, PhD in Immunology in 1991, Research Director (DR) at CNRS, partner of the LabEx PARAFRAP. She was the coordinator of the Laboratoire International Associé "Systems Immunology and genetic of Infectious Diseases" (LIA SIGID). She has done her PhD on Malaria immunology with Pr D. Mazier at CHU Pitié Salpêtriere and her Post Doc with Pr V. Chauhan at ICGEB, India. She has been group leader at the Infectious Immunophysiopathology unit, Department of Immunology at Institut Pasteur Paris from 2001-2008.  Since 2009, she directs a parasitology team at the CIIL in Lille. Her main research interest in the study of the complex nature of immune responses contributing to protection or pathology in parasite infection.  SP is strongly involved in teaching activities and co-responsible of ECTS of Immunoparasitology in the Master of Parasitology/mycology at Paris Sorbonne University. SP has hold several grants (EU, WHO, CEFIPRA, PAL+, ARCIR, PIME). She has organized several workshop, symposium and international courses in Immunology of parasitic diseases.

Head of team:

Magalie PIERRE-DEMAR

Contact

Magalie Pierre-Demar, PU-PH in parasitology and mycology since 2015 in French Guiana University, head of the Laboratory of Parasitology–Mycology at the Hospital of Cayenne (since 2014), director of the associated national center for leishmaniasis in French Guiana. She is also a member of the scientific committee of the CEBA (Centre de la Biodiversité Amazonienne). She has done her PhD on Toxoplasmosis epidemiology with Pr. Bernard Carme at CHU Antilles-Guyane. She has been the head of the research team "Amazonian ecosystems and tropical pathology" (EPaT) from 2017-2019.  Her main research interest is in the study of Amazonian toxoplasmosis and intestinal parasites.  Magalie Pierre-Demar is involved in teaching activities and Master training mostly in parasitology and mycology. She has hold several grants (PO-FEDER, Labex Ceba).

Research areas of the team

Infections by protozoa such as Plasmodium, Leishmania, Toxoplasma cause more chronic asymptomatic disease than acute severe illnesses in high endemicity areas. Such asymptomatic individuals develop anti-disease immunity and become reservoirs of parasites. In the natural ecosystems, diversity of parasite populations,  shared and/or individual environment including the host immune response and genetic background together contribute to immunity.  However, in such settings, immunity can be influenced by commensal and simultaneous infections with other parasites constituting the ‘multi-biome’ of the host.

The general objectives of the research project of the team are:

  1. To evaluate the complex nature of immune mechanisms induced by protozoan parasite (co)infections (Axis 1)
  2. To investigate how they are modulated by environmental factors and influence disease progression in the French Guiana Amazonian ecosystem (Axis 2)

The team develops a “one health” strategy by capitalizing on the strength and multidisciplinary expertise of the members (clinicians working on the field in FG, molecular parasitology and epidemiology, immunology).

Keswani T, Delcroix-Genete D, Herbert F, Leleu I, Lambert C, Draheim M, Salome-Desnoulez S, JM, Cazenave PA, Silvie O, Roland J and Pied S. (2020) Plasmodium yoelii Uses a TLR3-Dependent Pathway to Achieve Mammalian Host Parasitism.J Immunol. doi: 10.4049/jimmunol.1901317.

 

Mosnier E, Roux E, Cropet C, Lazrek Y, Moriceau O, Gaillet M, Mathieu L, Nacher M, Demar M, Odonne G, Douine M, Michaud C, Pelleau S, Djossou F, Musset L. (2020) Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana-Brazil): Associated Factors and Spatial Distribution.Am J Trop Med Hyg. doi: 10.4269/ajtmh.19-0378.

 

Mosnier E, Dusfour I, Lacour G, Saldanha R, Guidez A, Gomes MS, Sanna A, Epelboin Y, Restrepo J, Davy D, Demar M, Djossou F, Douine M, Ardillon V, Nacher M, Musset L, Roux E. (2020). Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil.BMC Infect Dis. doi: 10.1186/s12879-020-05086-4.

 

Blaizot R, Nabet C, Laghoe L, Faivre B, Escotte-Binet S, Djossou F, Mosnier E, Henaff F, Blanchet D, Mercier A, Dardé ML, Villena I, Demar M. (2020) Outbreak of Amazonian Toxoplasmosis: A One Health Investigation in a Remote Amerindian Community.Front Cell Infect Microbiol. doi: 10.3389/fcimb.2020.00401.

 

Ducharme O, Simon S, Ginouves M, Prévot G, Couppie P, Demar M, Blaizot R. (2020) Leishmania naiffi and lainsoni in French Guiana: Clinical features and phylogenetic variability. PLoS Negl Trop Dis. doi: 10.1371/journal.pntd.0008380.

 

Mathieu LC, Cox H, Early AM, Mok S, Lazrek Y, Paquet JC, Ade MP, Lucchi NW, Grant Q, Udhayakumar V, Alexandre JS, Demar M, Ringwald P, Neafsey DE, Fidock DA, Musset L. (2020) Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance. Elife. doi: 10.7554/eLife.51015.

 

Keswani T, Roland J, Herbert F, Delcroix-Genete D, Bauderlique-Le Roy H, Gaayeb L, Cazenave PA, Pied S. (2019) Expression of CD300lf by microglia contributes to resistance to cerebral malaria by impeding the neuroinflammation.  Genes Immun. doi: 10.1038/s41435-019-0085-9.

 

Chavy A, Ferreira Dales Nava A, Luz SLB, Ramírez JD, Herrera G, Vasconcelos Dos Santos T, Ginouves M, Demar M, Prévot G, Guégan JF, de Thoisy B. (2019) Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome.PLoS Negl Trop Dis. doi: 10.1371/journal.pntd.0007629.

 

Chavy A, Nabet C, Normand AC, Kocher A, Ginouves M, Prévot G, Vasconcelos Dos Santos T, Demar M, Piarroux R, de Thoisy B. (2019) Identification of French Guiana sand flies using MALDI-TOF mass spectrometry with a new mass spectra library.PLoS Negl Trop Dis. doi: 0.1371/journal.pntd.0007031.

 

Blaizot R, Nabet C, Blanchet D, Martin E, Mercier A, Dardé ML, Elenga N, Demar M. (2019) Pediatric Amazonian Toxoplasmosis Caused by Atypical Strains in French Guiana, 2002-2017. Pediatr Infect Dis J. doi: 10.1097/INF.0000000000002130.

 

Douine M, Sanna A, Hiwat H, Briolant S, Nacher M, Belleoud D, Le Tourneau FM, Bogreau H, De Laval F. (2019) Investigation of a possible malaria epidemic in an illegal gold mine in French Guiana: an original approach in the remote Amazonian forest.Malar J. doi: 10.1186/s12936-019-2721-2.

 

Loiseau R, Nabet C, Simon S, Ginouves M, Brousse P, Blanchet D, Demar M, Couppie P, Blaizot R. (2019) American cutaneous leishmaniasis in French Guiana: an epidemiological update and study of environmental risk factors.Int J Dermatol. doi: 10.1111/ijd.14625.

 

Valdes A, Epelboin L, Mosnier E, Walter G, Vesin G, Abboud P, Melzani A, Blanchet D, Blaise N, Nacher M, Demar M, Djossou F. (2018) Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison.Malar J. doi: 10.1186/s12936-018-2378-2.

 

Christen JR, Bourreau E, Demar M, Lightburn E, Couppié P, Ginouvès M, Prévot G, Gangneux JP, Savini H, de Laval F, Pommier de Santi V, Briolant S. (2018) Use of the intramuscular route to administer pentamidine isethionate in Leishmania guyanensis cutaneous leishmaniasis increases the risk of treatment failure.Travel Med Infect Dis. doi: 10.1016/j.tmaid.2018.02.010.

 

Douine M, Lazrek Y, Blanchet D, Pelleau S, Chanlin R, Corlin F, Hureau L, Volney B, Hiwat H, Vreden S, Djossou F, Demar M, Nacher M, Musset L. (2018) Predictors of antimalarial self-medication in illegal gold miners in French Guiana: a pathway towards artemisinin resistance.J Antimicrob Chemother. doi: 10.1093/jac/dkx343.

 

Shrivastava SK, Dalko E, Delcroix-Genete D, Herbert F, Cazenave PA, Pied S. (2017) Uptake of parasite-derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria. Glia. 65(1):75-92. doi: 10.1002/glia.23075.

 

Dalko E, Genete D, Auger F, Dovergne C, Lambert C, Herbert F, Cazenave PA, Roland J, Pied S. (2016) Heme dampens T-cell sequestration by modulating glial cell responses during rodent cerebral malaria. Brain Behav Immun. 58:280-290. doi: 10.1016/j.bbi.2016.07.157.

 

Herbert F, Tchitchek N, Bansal D, Jacques J, Pathak S, Bécavin C, Fesel C, Dalko E, Cazenave PA, Preda C, Ravindran B, Sharma S, Das B, Pied S. (2015) Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17pathway in acute renal failure associated to Plasmodium falciparum malaria. J Transl Med. 13:369. doi: 10.1186/s12967-015-0731-6.

 

Blanc AL, Keswani T, Gorgette O, Bandeira A, Malissen B, Cazenave PA, Pied S. (2015) Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria. Infect Immun. 84(1):329-38. doi: 10.1128/IAI.00717-15.