Tropical Biome & Immuno-Pathophysiology


Head of team:

Sylviane PIED

Contact

Sylviane Pied, PhD in Immunology in 1991, Research Director (DR) at CNRS, partner of the LabEx PARAFRAP. She was the coordinator of the Laboratoire International Associé Systems Immunology and genetic of Infectious Diseases (LIA SIGID). She has done her PhD on Malaria immunology with Pr D. Mazier at CHU Pitié Salpêtriere and her Post Doc with Pr V. Chauhan at ICGEB, India. She has been group leader at the Infectious Immunophysiopathology unit, Department of Immunology at Institut Pasteur Paris from 2001-2008.  Her main research interest in the study of the complex nature of immune responses contributing to protection or pathology in parasite infection.  SP is strongly involved in teaching activities and co-responsible of ECTS of Immunoparasitology in the Master of Parasitology/mycology at Paris Sorbonne University. SP has hold several grants (EU, WHO, CEFIPRA, PAL+, ARCIR, PIME). She has organized several workshop, symposium and international courses in Immunology of parasitic diseases.

Head of team:

Magalie Pierre-Demar

Contact

Magalie Pierre-Demar, PU-PH in parasitology and mycology since 2015 in French Guiana University, head of the Laboratory of Parasitology–Mycology at the Hospital of Cayenne (since 2014), director of the associated national center for leishmaniasis in French Guiana. She is also a member of the scientific committee of the CEBA (Centre de la Biodiversité Amazonienne). She has done her PhD on Toxoplasmosis epidemiology with Pr. Bernard Carme at CHU Antilles-Guyane. She has been the head of the research team "Amazonian ecosystems and tropical pathology" (EPaT) from 2017-2019.  Her main research interest is in the study of Amazonian toxoplasmosis and intestinal parasites.  Magalie Pierre-Demar is involved in teaching activities and Master training mostly in parasitology and mycology. She has hold several grants (PO-FEDER, Labex Ceba).

Research areas of the team

Infections by protozoa such as Plasmodium, Leishmania, Toxoplasma cause more chronic asymptomatic disease than acute severe illnesses in high endemicity areas. Such asymptomatic individuals develop anti-disease immunity and become reservoirs of parasites. In the natural ecosystems, diversity of parasite populations,  shared and/or individual environment including the host immune response and genetic background together contribute to immunity.  However, in such settings, immunity can be influenced by commensal and simultaneous infections with other parasites constituting the ‘multi-biome’ of the host.

The general objectives of the research project of the team are:

  1. To evaluate the complex nature of immune mechanisms induced by protozoan parasite (co)infections (Axis 1)
  2. To investigate how they are modulated by environmental factors and influence disease progression in the French Guiana Amazonian ecosystem (Axis 2)

The team develops a “one health” strategy by capitalizing on the strength and multidisciplinary expertise of the members (clinicians working on the field in FG, molecular parasitology and epidemiology, immunology).