We are looking for a technician to temporarily support the research of the Chemical Biology of Antibiotics (CBA) laboratory at the Centre of infection and Immunity of Lille, located at the Institut Pasteur of Lille. The Chemical Biology of Antibiotics (CBA) team is an international, cross-disciplinary team focused on the antibiotic drug discovery and development and work in organic chemistry, bacterial genetics, biochemistry, bacteriology and drug susceptibility testing...
More details: HERE
We are looking for a technician in organic chemistry to support antibiotic drug discovery research in the Chemical Biology of Antibiotics (CBA) team located at the Institut Pasteur of Lille. The CBA team is a cross-disciplinary team focused on the discovery and development of novel antibiotic molecules. As part of a ERC-COG funded program, ANTIBIOCLICKS, technical expertise in organic chemistry are sought in order to support the synthesis of a number of molecules.
More details: HERE
Post-doc position - T. gondii centrosome biology
Toxoplasma gondii is responsible for toxoplasmosis, a disease which can be fatal for the fetus of infected mothers and for immunocompromised patients. This parasite belongs to the Apicomplexa family which contains other parasites of medical importance such as Plasmodium (responsible for malaria) or Cryptosporidium (cryptosporidiosis). The pathogenicity of these parasites is based on their ability to divide in order to proliferate in the organism. They have therefore invented simplified division patterns in order to multiply efficiently and quickly while producing a large number of parasites. The mechanisms allowing the control and coordination of these modes of division are therefore essential to their ability to proliferate and therefore to the survival of these parasites in humans. We aim to expand our understanding on how these parasites are able to evolve flexible modes of division allowing them to proliferate in a large number of different organisms. We study the proteins that control and coordinate the division of these parasites, using T. gondii as a model Apicomplexa. We are particularly interested in centrosome proteins that orchestrate the cell cycle.
These studies could lead us to better understand the mechanisms of division in this family of parasites in order to develop new molecules aiming at controlling their proliferation.
We are looking for a highly motivated individual holding a PhD in biochemistry, molecular parasitology or a related field to explore the biological role of centrosome proteins of unknown function. We will use genetic modification of the parasite genome to produce mutants. We will explore the phenotype of these mutants using cutting-edge microscopy techniques. We will also use biochemistry to purify the centrosomal protein complexes.
Our lab is located at the Institut Pasteur de Lille that has state-of-the-art proteomic and microscopy facilities. Lille is a vibrant city located in the north of France and in the heart of Europe (1hr from London or Brussels)
The position is funded for two years.
Please send an email to Mathieu Gissot for further details.
To apply for this position, send a cover letter, a CV and the name of three referees to Mathieu Gissot
Postdoc position offer
The "Lung Infection and Innate Immunity" laboratory is mainly interested in two clinically relevant pathogens: influenza A virus and Streptococcus pneumoniae. Our objectives are (i) to define host molecular and cellular factors that predispose to bacterial infections in the context of pulmonary inflammation (such as during flu) and metabolic disorders and (ii) to develop new strategies to strengthen host defense mechanisms against respiratory pathogens.
To reinforce our research activities, we aim to welcome a young scientist with the potential to be recruited as a permanent scientist in our team and to bring complementary expertise. A minimal 3-year postdoc is required. Interested applicants can send a letter explaining why they are interested and their curriculum vitae by email.