Biology of Apicomplexan Parasites

The apicomplexan parasites Plasmodium and Toxoplasma gondii, causative agents of malaria and toxoplasmosis respectively, continue to present a public health menace and to weigh heavily on the socio-economic development in certain regions. Once inside host cells, these parasites set up a highly coordinated gene expression programs to promote their growth/differentiation. Concomitantly, diverse biological processes including post translational modifications (in particular reversible protein phosphorylations) of expressed proteins and their trafficking are initiated to keep their functions in fine-tuning with the progress of parasites life cycles. Our current research is focusing on reversible phosphorylation processes with particular emphasis on issues related to phosphatases and their regulation. Currently, our studies are mainly dedicated to explore the function and regulation of Plasmodium/Toxoplasma protein phosphatase type 1 or PP1, an essential ser/thr phosphatase for the (sur)vival of any eukaryotic cell. The final goal of our basic research is to provide a better understanding of the molecular events contributing to the life cycles progression of these parasites and, ultimately, to control malaria and toxoplasmosis by translating the new fundamental knowledge into the development of therapeutic strategies.