The Chemical Biology of Antibiotics (CBA) research team is headed Ruben Hartkoorn and is focused on discovering new antibiotics to target drug resistant bacteria. There is currently a frightening increase in antibiotic resistance that is threatening our global healthcare system, possibly sending us back to the pre-antibiotic era of the 19th century. The drug resistant bacteria that pose a fundamental medical urgency are now officially prioritised by the WHO and include M. tuberculosis as well as important nosocomial bacteria. The CBA team focusses its antibiotic research on M. tuberculosis, A. baumannii, Enterobacteriaceae, P. aeruginosa, S. aureus and S. pneumoniae. The CBA team focuses on (1) discoveringnovel antibiotic classes that target drug resistant and tolerant bacteria, (2) the vectorisation of antibiotics to improve bacterial penetration, (3) antibiotic efflux pump inhibitors in Gram-negative bacteria, and finally (4) defining novel mechanisms of antibiotic resistance.