See the updated list of projects HERE


Cell Physics and surface signalling linked of host-pathogen interactions

  • Biomechanics of Listeria monocytogenes–host cell interaction (with P Cossart Inst Pasteur Paris)

  • Biophysics of Trans- Endothelial Macroapertures induced by bacterial toxins (with E Lemichez Inst Pasteur Paris)

  • Neisseria interaction with plasma membrane: adhesion forces (With S Bourdoulous Inst Cochin)

  • Signaling associated to the interaction of Yersinia to the cell surface

  • Imaging at high speed membrane dynamics and protein/lipid interactions

  • Biophysics of host-pathogen interaction at the nanometric scale

  • Structure and dynamics of SNARE calcium-sensitive oligomers for synaptic vesicle transmission (with JE Rothmans Yale Univ)

  • Nano-mechanics response measurements of cells and tissues in cancer (EU ITN consortium)

  • Towards automation for nano-mechanics characterization of biological samples in diseases

     

Autophagie et infection

  • Mécanismes de la marche en autophagie pendant les phases vacuolaires de l'infection bactérienne: Yersinia pseudotuberculosis
  • Rôle de l'autophagie en réponse aux dommages membranaires: Shigella (avec P Sansonetti Inst Pasteur Paris) et Coxiella (avec MI Colombo Univ Mendoza)
  • Rôle de l'autophagie dans les réponses cellulaires à l'infection à norovirus
  • Caractérisation de la régulation de l'autophagie par les bactéries lactiques à la fois in vitro et in vivo

Collaborations

  • Cytoadhesion of Plasmodium falciparum-infected erythrocytes, ultrastructural characterization and elastic properties of knobs studied with AFM
  • Ultrastructural analysis of osteoblasts mineralization
  • Characterization of hydrophobins from Aspergillus fumigatus
  • Adhesive properties of Staphylococcus aureus

Technologies and Developments

  • Atomic Force Microscopy and super-resolution fluorescence microscopy correlative method: Ciczora et al 2019 Biol Cell
  • CLAFEM: Correlative Light Atomic Force Electronic Microscopy : Janel et al 2017 Methods in Cell Biology
  • CLEM: Correlative Light Electron Microscopy on host-pathogen interaction Ligeon & al 2015 Methods
  • Stiffness tomography of intracellular organelles : Roduit et al 2008,2009 Biophys J, Janel et al Nanoscale 2019
  • AFM automation: Dujardin et al PLoS ONE 2019
  • AFM Measurement standardization for cells and tissues: Schillers et al 2017 Sci Rep