Chemical Biology of Flatworms: Identifying the molecular determinants of Schistosoma mansoni reproduction
The CBF team is involved in fundamental research on schistosomes using integrated chemical biology approaches. The main goal is the discovery and the development of novel therapeutic strategies against schistosomiasis.
The team is particularly focussed on the study of Schistosoma mansoni (S. mansoni). The life-cycle of S. mansoni, maintained by the team in a new dedicated lab requires two hosts, a fresh water snail Biomphalaria glabrata (B. glabrata) and a mammalian host (hamsters).
For more informations on S. mansoni life-cycle and how this worm is maintained in the lab, please visit our dedicated website: S. mansoni laboratory
The biology research of S. mansoni is strongly integrated with the expertise of the team in protein chemical synthesis and protein design, which also constitutes an important axis of research.
To have a large overview of our research in protein chemical synthesis, please visit our dedicated website: Protein chemical synthesis
Cyclic peptides can be produced in a few minutes by cyclization in a microfluidic system.
See our article in Nature Communications: Ollivier, O et al. Nature Comunications 2018
The life-cycle of Schistosoma mansoni