Amide Chemistry Enables Redox Locking of Cyclic Disulfides for Polypeptide Assembly
09/23/2025
A practical strategy in synthetic organic chemistry for shutting down temporarily the nucleophilicity of thiols is to exploit their redox properties by converting them into disulfides.
The stability of such athiol protection in reductive medium can be sensitive to microenvironmental changes, including chemical modifications occurring nearby.
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