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Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19

04/08/2025

Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role of age-associated dysbiosis on disease outcomes is still elusive

Older adults (over ~65 years) are particularly susceptible to respiratory viral infections, including those caused by influenza A viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease-19 (COVID-19). This greater susceptibility to viral infections in the elderly is related to declines in pulmonary function and immune response, as well as altered recovery, prolonging the duration of sequelae ...

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