Researchers in Lille propose a New Treatment for Bacterial Pneumonia

One of the primary goals of the research team “Bacteria, Antibiotics & Immunity” is to optimize treatments for pneumococcal pneumonia, particularly against infections caused by antibiotic-resistant strains. In a recent article published in the Journal of Infectious Diseases, the team demonstrates that by activating the immune system with a bacterial compound called flagellin in combination with the antibiotic amoxicillin, it is possible to more effectively combat the infection and promote recovery. The study shows that flagellin not only allows for a 200-fold reduction in the antibiotic dose but also prevents the emergence of antibiotic-resistant strains. A mathematical model confirmed the potential of the thrapeutic approach. This discovery paves the way for new treatments that leverage our natural immune defenses and reduce the reliance on antibiotics.

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