Publications


Selected Publications


Montpellier C, Wychwoski C, Sayed IM, Meunier JC, Saliou JM, Ankavay M, Bull A, Pillez A, Abravanel F, Helle F, Brochot E, Drobecq H, Farhat R, Aliouat-Denis CM, Haddad J, Izopet J, Meuleman P, Goffard A, Dubuisson J, Cocquerel L. (2018) Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein. Gastroenterology, 154, 211-223

Belouzard S, Danneels A, Lucie Fénéant L, Séron K, Rouillé Y, Dubuisson J. (2017) Entry and release of hepatitis C virus in polarized human hepatocytes. J Virol, 2017, 91, e00478-17

Haddad JG, Rouillé Y, Hanoulle X, Descamps V, Hamze M, Dabboussi F, Baumert TF, Duverlie G, Lavie M, Dubuisson J. (2017) Identification of novel functions for HCV envelope glycoprotein E1 in virus entry and assembly. J Virol, 91, e00048-17

Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y. (2016) Morphology and molecular composition of purified bovine viral diarrhea virus envelope. PLoS Pathog, 12, e1005476

Farhat R, Séron K, Ferlin J, Fénéant L, Belouzard S, Goueslain L, Jackson CL, Dubuisson J, Rouillé Y. (2016) Identification of class II ADP-ribosylation factors as cellular factors required for hepatitis C virus replication. Cell Microbiol, 18, 1121-1133

Calland N, Sahuc ME, Belouzard S, Pène V, Bonnafous P, Mesalam AA, Deloison G, Descamps V, Sahpaz S, Wychowski C, Lambert O, Brodin P, Duverlie G, Meuleman P, Rosenberg AR, Dubuisson J, Rouillé Y, Séron K. (2015) Polyphenols inhibit hepatitis C virus entry by a new mechanism of action. J Virol, 89, 10053-10063

Vausselin T, Calland N, Belouzard S, Descamps V, Douam F, Helle F, François C, Lavillette D, Duverlie G, Wahid A, Fénéant L, Cocquerel L, Guérardel Y, Wychowski C, Biot C, Dubuisson J. 2013. The antimalarial ferroquine is an inhibitor of hepatitis C virus. Hepatology, 58, 86-97

Potel J, Rassam P, Montpellier C, Kaestner L, Werkmeister E, Tews BA, Couturier C, Popescu CI, Baumert T, Rubinstein E, Dubuisson J, Milhiet PE, Cocquerel L. 2013. EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry. Cell Microbiol, 15, 1234–1252

Albecka A, Belouzard S, Op de Beeck A, Descamps V, Goueslain L, Bertrand-Michel J, Tercé F, Duverlie G, Rouillé Y, Dubuisson J. 2012. Role of LDL receptor in the hepatitis C virus life cycle. Hepatology, 55, 998-1007

Popescu CI, Callens N, Trinel D, Roingeard P, Moradpour D, Descamps V, Duverlie G, Penin F, Héliot L, Rouillé Y, Dubuisson J. 2011. NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PLoS Pathog, 7, e1001278


Sahuc ME, Sahli R, Rivière C, Pène V, Lavie M, Vandeputte A, Brodin P, Rosenberg AR, Dubuisson J, Ksouri R, Rouillé Y, Sahpaz S, Séron K. Dehydrojuncusol, a natural phenanthrene compound extracted from Juncus maritimus is a new inhibitor of hepatitis C virus replication. J Virol, 2019, 93, in press


Moustafa RI, Dubuisson J, Lavie M. Function of the hepatitis C virus E1 glycoprotein in viral entry and assembly. Future Virology, 2019, in press


Handala L, Fiore T, Rouillé Y, Helle F. An ImageJ macro to automatically determine the percentage of infected cells after immunofluorescence. Viruses, 2019, in press


Lebsir N, Goueslain L, Farhat R, Callens N, Dubuisson J, Jackson CL, Rouillé Y. Functional and physical interaction between the Arf activator GBF1 and hepatitis C virus NS3 protein. J Virol, 2019, 93, e01459-18


Riva L, Dubuisson J. Similarities and differences between HCV pseudoparticle (HCVpp) and cell culture HCV (HCVcc) in the study of HCV. Methods in Molecular Biology, 2019, 1911, 33-45


Chowdhury P, Sahuc ME, Rouillé Y, Rivière C, Bonneau N, Vandeputte A, Brodin P, Goswami M, Bandyopadhyay T, Dubuisson J, Séron K. (2018) Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture. PLoS ONE, 13, e0198226


Lavie M, Hanoulle X, Dubuisson J (2018) Glycan shielding and modulation of hepatitis C virus neutralizing antibodies. Frontiers Immunol 9, 910


Ankavay M, Dubuisson J, Cocquerel L. Le virus de l’hépatite E, un virus méconnu qui se dévoile. Médecine/Sciences, 2018, 34, 1071-1078

Moudjahed H, Pinçon C, Alidjinou K, Dewilde A, Goffard A. (2018) Comparison of three molecular assays for detection of enteric viruses in stool samples. J Virol Methods, 250, 55-58


Farhat R, Ankavay M, Lebsir N, Gouttenoire J, Jackson CL, Wychowski C, Weber A, Moradpour D, Dubuisson J, Rouillé Y, Cocquerel L. (2018) Identification of GBF1 as a cellular factor required for Hepatitis E virus RNA replication. Cell Microbiol, 20, e12804


Riva L, Song OR, Prentoe J, Helle F, L'homme L, Gattolliat CH, Vandeputte A, Fénéant L, Belouzard S, Baumert T, Asselah T, Bukh J, Brodin P, Cocquerel L, Rouillé Y, Dubuisson J. (2018) Identification of piperazinylbenzenesulfonamides as new inhibitors of claudin-1 trafficking and Hepatitis C Virus entry. J Virol, 92, e01982-17


Grünvogel O, Colasanti O, Lee JY, Klöss V, Belouzard S, Reustle A, Esser-NobisK, Hesebeck-Brinckmann J, Mutz Pi, Hoffmann K, Mehrabi A, Koschny R, Vondran FWR, Gotthardt D, Schnitzler P, Neumann-Haefelin C, Thimme R, Binder M, Bartenschlager R, Dubuisson J, Dalpke AH, Lohmann V. (2018) Secretion of hepatitis C virus replication intermediates dampens toll-like receptor 3 activation in hepatocytes. Gastroenterology, 154, 2237-2251


Bonnin A, Danneels A, Dubuisson J, Goffard A, Belouzard S. (2018) HCoV-229E spike protein fusion activation by trypsin-like serine proteases is mediated by proteolytic processing in the S2’ region. J Gen Virol, 99, 908-912


Ferlin J, Farhat R, Belouzard S, Cocquerel L, Bertin A, Hober D, Dubuisson J, Rouillé Y. (2018) Investigation of the role of GBF1 in the replication of positive-sense single-stranded RNA viruses. J Gen Virol, 99, 1086-1096


Lancel S, Hesselink MCK, Woldt E, Rouillé Y, Dorchies E, Delhaye S, Duhem C, Thorel Q, Mayeuf-Louchart A, Pourcet B, Montel V, Schaart, G, Beton N, Picquet F, Briand O, Salles JP, Duez H, Schrauwen P, Bastide B, Bailleul B, Staels B, Sebti Y. (2018) Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity. JCI Insight, 3, pii:98081


Moustafa R, Haddad J, Linna L, Hanoulle X, Descamps V, Mesalam A, Baumert T, Duverlie G, Meuleman P, Dubuisson J*, Lavie M*. Functional study of the C-terminal part of hepatitis C virus E1 ectodomain. J Virol, 2018, 92, e00939-18


Lavie M, Hanoulle X, Dubuisson J (2018) Glycan shielding and modulation of hepatitis C virus neutralizing antibodies. Frontiers Immunol 9, 910

Fournier C, Hoffmann TW, Morel V, Descamps V, Dubuisson J, Brochot E, Francois C, Duverlie G, Castelain S, Helle F. (2018) Claudin-1, miR-122 and Apolipoprotein E transduction improves the permissivity of SNU-182, SNU-398 and SNU-449 Hepatoma cells to Hepatitis C Virus. J Viral Hepatitis, 25, 63-71


Montpellier C, Wychwski C, Sayed IM, Meunier JC, Saliou JM, Ankavay M, Bull A, Pillez A, Abravanel F, Helle F, Brochot E, Drobecq H, Farhat R, Aliouat-Denis CM, Haddad J, Izopet J, Meuleman P, Goffard A, Dubuisson J, Cocquerel L. (2018) Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein. Gastroenterology, 154, 211-223

Mesalam, AA, Desombere I, Farhoudi A, Van Houtte F, Verhoye L, Ball J, Dubuisson J, Foung SKH, Patel AH, Persson MAA, Leroux-Roels G, Meuleman P. (2018) Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1. Virology, 514, 30-41

Haddad JG, Rouillé Y, Hanoulle X, Descamps V, Hamze M, Dabboussi F, Baumert TF, Duverlie G, Lavie M, Dubuisson J. (2017) Identification of novel functions for HCV envelope glycoprotein E1 in virus entry and assembly. J Virol, 91, e00048-17

Sayed IM, Verhoye L, Cocquerel L, Abravanel F, Foquet L, Montpellier C,Debing Y, Farhoudi A, Wychowski C, Dubuisson J, Leroux-Roels G,  Neyts J, Izopet J, Michiels T, Meuleman P. (2017) Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanized liver. Gut, 66, 920-929

Liu-clarke J, Paruch L, Dobrica MO, Caras I, Tucureanu C, Onu A, Ciulean S, Stavaru C, van Eerde A, Steen H, Haugslien S, Petrareanu C, Lazar C, Popescu I, Bock R, Dubuisson J, Branza-Nichita N. (2017) Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination. Plant Biotechnol J, 15, 1611-1621

Vlaicu O, Selescu T, Pastrama F, Munteanu C, Riva L, Dubuisson J, Rouille Y, Popescu CI. (2017) Novel replicons and trans-encapsidation systems for Hepatitis C Virus proteins live imaging and virus-host interaction proteomics. J Virol Methods, 246, 42-50

Sahli R, Rivière C, Neut C, Bero J, Sahuc ME, Smaoui A, Beaufay C, Roumy V, Hennebelle T, Rouillé Y, Quetin-Leclercq J, Séron K, Ksouri R, Sahpaz S. (2017) An ecological approach to discover new bioactive extracts and products: the case of extremophile plants. J Pharm Pharmacol, 69, 1041-1055

Lavie M, Dubuisson J. (2017) Interplay between hepatitis C virus and lipid metabolism during virus entry and assembly. Biochimie, 141, 62-69.

Belouzard S, Danneels A, Lucie Fénéant L, Séron K, Rouillé Y, Dubuisson J. (2017) Entry and release of hepatitis C virus in polarized human hepatocytes. J Virol, 2017, 91, e00478-17

Florian PE, Rouillé Y, Ruta S, Nichita N, Roseanu A. (2016) Recent advances in human viruses imaging studies. J Basic Microbiol, 56, 591-607

Millet JK, Séron K, Labitt RN, Danneels A, Palmer KE, Whittaker GR, Dubuisson J, Belouzard S. (2016) Middle East Respiratory Syndrome Coronavirus infection is inhibited by Griffithsin. Antiviral Res, 133, 1-8

Vausselin T, Séron K, Lavie M, Atef Mesalam AA, Lemasson M, Belouzard S, Fénéant L, Danneels A, Rouillé Y, Cocquerel L, Foquet L, Rosenberg AR, Wychowski C, Meuleman P, Melnyk P, Dubuisson J. (2016) Identification of a new benzimidazole derivative as an antiviral against hepatitis C virus. J Virol, 90, 8422-8434

Vauthier V, Roujeau C, Chen P, Sarkis C, Migrenne S, Hosoi T, Ozawa K, Rouillé Y, Foretz M, Mallet J, Launay JM, Magnan C, Jockers R, Dam J. (2016) Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling. Mol Metab, 6, 159-172

Sahli R, Rivière C, Sahuc ME, Abderrazak S, Samaillie J, Roumy V, Hennebelle T, Rouillé Y, Seron K, Sahpaz S, Ksouri R. (2016) A new inhibitor of hepatitis C virus replication from Juncus maritimus, a Tunisian extremophile plant. Planta Med, 2016, 82, S1-S381

Sayed IM, Verhoye L, Cocquerel L, Abbravanel F, Foquet L, Montepellier C,Debing Y, Farhoudi A, Wychowski C, Dubuisson J, Leroux-Roels G,  Neyts J, Izopet J, Michiels T, Meuleman P. (2016) Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanized liver. Gut, in press.

Vausselin T, Séron K, Lavie M, Atef Mesalam AA, Lemasson M, Belouzard S, Fénéant L, Danneels A, Rouillé Y, Cocquerel L, Foquet L, Rosenberg AR,  Wychowski C, Meuleman P, Melnyk P, Dubuisson J. (2016) Identification of a new benzimidazole derivative as an antiviral against hepatitis C virus. J Virol, 90, 8422-8434



Millet JK, Séron K, Labitt RN, Danneels A, Palmer KE, Whittaker GR, Dubuisson J, Belouzard S. (2016) Middle East Respiratory Syndrome Coronavirus infection is inhibited by Griffithsin. Antiviral Res, 133, 1-8



Farhat R, Séron K, Ferlin J, Fénéant L, Belouzard S, Goueslain L, Jackson CL, Dubuisson J, Rouillé Y. (2016) Identification of class II ADP-ribosylation factors as cellular factors required for hepatitis C virus replication. Cell Microbiol, 18, 1121-1133



Callens N, Brügger B, Bonnafous P, Drobecq H, Gerl MJ, Krey T, Roman-Sosa G, Rümenapf T, Lambert O, Dubuisson J, Rouillé Y. (2016) Morphology and molecular composition of purified bovine viral diarrhea virus envelope. PLoS Pathog., 12, e1005476



Galani BR, Sahuc ME, Sass G, Njayou FN, Loscher C, Mkounga P, Deloison G, Brodin P, Rouillé Y, Tiegs G, Séron K, Moundipa PF. (2016) Khaya grandifoliola C.DC : a potential source of active ingredients against hepatitis C virus in vitro. Arch Virol, 161, 1169-1181



Baumert TF, Schuster C, Cosset FL, Dubuisson J, Hofmann M, Tautz N, Zeisel MB, Thimme R. (2016) Addressing the Next Challenges: a Summary of the 22nd International Symposium on Hepatitis C Virus and Related Viruses. J Hepatol, 64, 968-973



Goffard A, Demanche C, Arthur L, Michaux J, Dubuisson J. (2015) Alphacoronaviruses detected in French bats are phylogeographically linked to coronaviruses of European bats. Viruses, 7, 6279-6290



Xu Y, Martinez P, Séron K, Luo G, Allain F, Dubuisson J, Belouzard S. (2015) Characterization of hepatitis C virus interaction with heparan sulfate proteoglycans. J Virol, 89, 3846-3858.



Fénéant L, Cocquerel L. (2015) SRFBP1, an additional player in HCV entry. Trends Microbiol, 23, 590-593



Fénéant L, Ghosn J, Fouquet B, Helle F, Belouzard S, Vausselin T, Séron K, Delfraissy JF, Dubuisson J, Misrahi M, Cocquerel L. (2015) Claudin-6 and Occludin natural variants found in a patient highly exposed but not infected with Hepatitis C Virus (HCV) do not confer HCV resistance in vitro. PLoS ONE, 10, e0142539.

Fénéant L, Potel J, François C, Sané F, Douam F, Bélouzard S, Calland N, Vausselin T, Rouillé Y, Descamps V, Baumert T, Duverlie G, Lavillette D, Hober D, Dubuisson J, Wychowski C, Cocquerel L. (2015) New insights into the understanding of hepatitis C virus entry and cell-to-cell transmission by using the ionophore Monensin A. J Virol, 89, 8346-8364.



Falson P, Bartosch B, Alsaleh K, Tews BA, Loquet A, Ciczora Y, Riva L, Montigny C, Montpellier C, Duverlie G, Pécheur EI, le Maire M, Cosset FL, Dubuisson J, Penin F. (2015) Hepatitis C virus envelope glycoprotein E1 forms trimers at the surface of the virion. J Virol, 89, 10333-10346.



Calland N, Sahuc ME, Belouzard S, Pène V, Bonnafous P, Mesalam AA, Deloison G, Descamps V, Sahpaz S, Wychowski C, Lambert O, Brodin P, Duverlie G, Meuleman P, Rosenberg AR, Dubuisson J, Rouillé Y, Séron K. (2015) Polyphenols inhibit hepatitis C virus entry by a new mechanism of action. J Virol, 89, 10053-10063.



Lavie M, Sarrazin S, Montserret R, Descamps V, Baumert T, Duverlie G, Séron K, Penin F, Dubuisson J. (2014) Identification of conserved residues in HCV envelope glycoprotein E2 modulating virus dependence on CD81 and SRB1 entry factors. J. Virol., 88, 10584-10597



Vausselin T, Calland N, Belouzard S, Descamps V, Douam F, Helle F, François C, Lavillette D, Duverlie G, Wahid A, Fénéant L, Cocquerel L, Guérardel Y, Wychowski C, Biot C, Dubuisson J. (2013) The antimalarial ferroquine is an inhibitor of hepatitis C virus. Hepatology, 58, 86-97.



Anjum S, Wahid A, Afzal MS, Albecka A, Alsaleh K, Tahir A, Baumert T, Wychowski C, Qadri I, Penin F, Dubuisson J. (2013) Glycosylation within a specific hypervariable region of subtype 3a of hepatitis C virus protects against virus neutralization. J. Infect. Dis., 208, 1888-1897.



Wahid A, Helle, F, Descamps V, Duverlie G, Penin F, Dubuisson J. (2013) Disulfide bonds in HCV glycoprotein E1 control the assembly and entry functions of E2 glycoprotein. J Virol, 87, 1605-1617.



Potel J, Rassam P, Montpellier C, Kaestner L, Werkmeister E, Tews BA, Couturier C, Popescu CI, Baumert T, Rubinstein E, Dubuisson J, Milhiet PE, Cocquerel L. (2013) EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry. Cell. Microbiol., 15, 1234–1252.



Calland N, Albecka A, Belouzard S, Wychowski C, Duverlie G, Descamps V, Hober D, Dubuisson J, Rouillé Y, Séron K. (2012) (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry. Hepatology, 55, 720-729.



Albecka A, Belouzard S, Op de Beeck A, Descamps V, Goueslain L, Bertrand-Michel J, Tercé F, Duverlie G, Rouillé Y, Dubuisson J. (2012) Role of LDL receptor in the hepatitis C virus life cycle. Hepatology, 55, 998-1007.



Albecka A, Montserret R, Krey T, Tarr AW, Diesis E, Ball JK, Descamps V, Duverlie G, Rey F, Penin F, Dubuisson J. (2011) Identification of new functional regions in hepatitis C virus envelope glycoprotein E2. J Virol, 85, 1777-1792.



Popescu CI, Callens N, Trinel D, Roingeard P, Moradpour D, Descamps V, Duverlie G, Penin F, Héliot L, Rouillé Y, Dubuisson J. (2011) NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PLoS Pathog, 7, e1001278.



Montpellier C, Tews B, Proitrimole J, Rocha-Perugini V, D’Arienzo V, Potel J, Zhang XA, Rubinstein E, Dubuisson J, Cocquerel L. (2011) Biochemical and functional characterization of CD81 interaction with two of its partners, EWI-2 and EWI-2wint. J Biol Chem, 286, 13954-13965.



Meuleman P, Albecka A, Belouzard S, Vercauteren K, Verhoye L, Wychowski C, Leroux-Roels G, Palmer KE, Dubuisson J. (2011) Griffithsin has antiviral activity against hepatitis C virus. Antimicrob Agents Chemother. 55, 5159-5167.



Goueslain L, Alsaleh K, Horrelou P, Roingeard P, Descamps V, Duverlie G, Ciczora Y, Wychowski C, Dubuisson J, Rouillé Y. 2010. Identification of GBF1 as a cellular factor required for HCV RNA replication. J Virol, 84, 773-787.



Vieyres G, Thomas X, Descamps V, Duverlie G, Patel AH, Dubuisson J. (2010) Characterization of the envelope glycoproteins associated with infectious hepatitis C virus. J Virol, 84, 10159-10168.



Helle F, Vieyres G, Elkrief L, Popescu CI, Wychowski C, Descamps V, Castelain S, Roingeard P, Duverlie G, Dubuisson J. (2010) Role of N-linked glycans in the functions of HCV envelope proteins incorporated into infectious virions. J Virol, 84, 11905-11915.

Publications