Publications


2020

Sencio V, Barthelemy A,Tavares LP, Gomes Machado M, Soulard D, Cuinat C, Noordine ML, Salomé-Desnoulez S, Deryuter L, Foligné B, Wahl C, Frisch B, Thomaz Viera A, Paget C, Milligan G, Ulven T, Wolowczuk I,  Faveeuw C, Le Goffic R, Thomas M, Ferreira S, Mauro M Teixeira MM and Trottein F.
Gut dysbiosis during influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production. Cell Reports. 30, 2934.

Hrdý J, Alard J, Couturier-Maillard A, Boulard O, Boutillier D, Delacre M, Lapadatescu C, Cesaro A, Blanc P, Pot B, Ryffel B, Chamaillard M and Grangette C. Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses. Scientific Reports.

Hassane M, Jouan Y, Creusat F, Soulard D, Boisseau C, Gonzalez L, Patin EC, Heuzé-Vourc'h N, Sirard JC, Faveeuw C, Trottein F, Si-Tahar M, Baranek T, Paget C (2020). Interleukin-7 protects against bacterial respiratory infection by promoting IL-17-A-producing innate T-cell response.
Mucosal immunology. 13 :128

2019

Paget C, Deng S, Soulard, D, Priestman DA, Speca S,  von Gerichten ., Speak AO, Mallevaey, T, Pewzner-Jung Y, Futerman AH, Faveeuw C, Platt FM., Sandhoff R and Trottein, F. Mammalian ganglioside species with specific ceramide backbones activate invariant Natural Killer T cells.
Plos Biology 17(3):e3000169.

von Gerichten J, Lamprecht D, Lukáš Opálka L, Soulard D, Marsching C, Pilz R, Sencio V, Herzer S, Galy B, Nordström  V, Hopf C, Gröne HJ, Trottein F and Sandhoff R (2019). Chromatographic/mass spectrometric identification of bacteria-derived immunogenic α-Galactosylceramide in the murine large intestine shows dependency on diet and inflammation.
J Lipid Res. 129:31

Georgel AF, Cayet D, Pizzorno A, Rosa-Calatrava M, Paget C, Sencio V, Dubuisson J, Trottein F, Sirard JC, Carnoy C.Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir. Antiviral. Res. 168: 28.

Zaylaa M, Alard J, Kassaa IA, Peucelle V, Boutillier D, Desramaut J, Rosenstiel P, Nguyen HTT, Dabboussi F, Pot B, Grangette C. Autophagy: A Novel Mechanism Involved in the Anti-Inflammatory Abilities of Probiotics.
Cell. Physiol. Biochem. 53:774

Belguesmia Y, Alard J, Mendil R, Ravallec R, Grangette C, Drider D, Cudennec B. In vitro probiotic properties of selected Lactobacilli and multi-strain consortium on immune function, gut barrier strengthening and gut hormone secretion.
J. Funct. Foods. 57:382.

Paget C & Trottein F. Mechanisms of bacterial superinfection post-influenza : the role of non-conventional T cells.  Front. Immunol.10: 336.

Trottein F, Alcorn JF. Editorial: Secondary Respiratory Infections in the Context of Acute and Chronic Pulmonary Diseases. Front Immunol. 10: 2764.

2018

Beshara R, Sencio V, Soulard D, Barthélémy A, Fontaine J,  Pinteau T, Bachar Ismail M,  Paget C, Sirard JC, Trottein F, Faveeuw C. Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during severe influenza contributes to bacterial superinfection.
Plos Pathogens. 14(10): e1007360

Patin E, Soulard D, Fleury S, Hassane M, Dombrowicz D, Faveeuw C, Trottein F and Paget C. Type I IFN receptor signalling controls IL-7-dependent accumulation and activity of protumoural IL-17A-producing γδT cells in breast cancer.
Cancer. Res. 78: 195.

Barthelemy A., Sencio V, Soulard D, Deruyter L, Faveeuw C, Le Goffic R and Trottein F. Interleukin-22 immunotherapy during severe influenza enhances lung tissue integrity and reduces secondary bacterial systemic invasion.
Infect. Immun. 86(7). pii: e00706-17

Madouri F, Barada O, Kervoaze G, Trottein F, Pichavant M, Gosset P. Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae.
eBioMedicine 37 : 417

Solans L, Debrie AS, Borkner L, Aguiló N, Thiriard A, Coutte L, Uranga S, Trottein F, Martín C, Mills KHG, Locht C. IL-17-dependent sIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine. Mucosal Immunol.
 Mucosal. Immunol. 11: 1753.

Prasanna M, Soulard D, Camberlein E, Ruffier N, Lambert A, Trottein F, Csaba N, Grandjean C. Semisynthetic glycoconjugate based on dual role protein/PsaA as a pneumococcal vaccine.
Eur. J. Pharm. Sci. 129 :31.

Alard J, Peucelle V, Boutillier D, Breton J, Kuylle S, Pot B, Holowacz S, Grangette C. New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches.
Benef. Microbes. 9: 317

Zaylaa M. Al Kassaa I, Alard J, Peucelle V, Boutillier D, Desramaut J, Dabboussi F, Pot B and Grangette C. Probiotics in IBD: Combining in vitro and in vivo models for selecting strains with both anti-inflammatory potential as well as a capacity to restore the gut
epithelial barrier.
J. Funct. Foods. 47: 304.

Trottein & Paget. Natural killer T cells and mucosal-associated invariant T cells in lung infections. Front. Immunol. 9:1750.

 

2017

Barthelemy A, Ivanov S, Hassane M, Frisch B, Faveeuw, C, Paget C and Trottein F. Exogenous activation of invariant Natural Killer T cells by -galactosylceramide reduces pneumococcal outgrowth and dissemination postinfluenza.
MBio 7(6). pii: e01440-16.

Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin E, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F and Paget C.  Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response
in respiratory bacterial infections.
Muc. Immunol. 10:1056.

Ghinnagow R, De Meester J, Cruz LJ, Aspord C, Corgnac S, Macho-Fernandez E, Soulard D, Fontaine J,  Chaperot L, Soncin F, Mami-Chouaib F, Plumas J, Faveeuw C and Trottein F. Co-delivery of the NKT agonist alpha-galactosylceramide and tumor antigens to cross-priming dendritic cells breaks tolerance to self-antigens and promotes antitumor responses.
OncoImmunology 6(9):e1339855.

Macho-Fernandez E, Chekkat N, Ehret C, Thomann JS, De Giorgi M, Spanedda V, Bourel-Bonnet L, Betbeder D, Heurtault B, Faveeuw C, Fournel S, Frisch B and Trottein F. Solubilization of -galactosylceramide in aqueous medium: impact on Natural Killer T cell activation and on antitumor responses.
Int. J. Pharmacol. 530:354.

Porte R, Van Maele L, Munoz-Wolf N, Foligne B, Dumoutier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, Carnoy C (2017) Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.
Infect. Immun. 85 (2). pii: e00806-16.

Sharan R, Perez-Cruz M, Kervoaze G, Gosset P, Weynants V, Godfroid F, Hermand P, Trottein F, Pichavant M, Gosset P (2017) Interleukin-22 protects against non-typeable Haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease.
Mucosal. Immunol. 10: 139.

Saroha A, Pewzner-Jung Y, Sharma P, Kelly S, Merrill Jr AH, Trottein F, Paget C, Lang KS and Futerman AH. Critical Role for Very-long Chain Sphingolipids in Invariant Natural Killer T cell Development and Homeostasis.
Front. Immunol. 8:1386.

Tavares LP, Garcia CC, Machado MG, Queiroz-Junior CS, Barthelemy A, Trottein F, Brandolini L, Allegretti M, Machado AM, de Sousa LP and Teixeira MM. CXCR1/2 antagonism is protective during influenza and post-influenza pneumococcal infection.
Front. Immunol 8:1799.

Guillon A, Brea D, Morello E, Tang A, Jouan Y, Ramphal R, Korkmaz B, Perez-Cruz M, Trottein F, O'Callaghan RJ, Gosset P, Si-Tahar M. Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.
Virulence 8: 810-820.

Burns P, Alard J, Hrdỳ J, Boutillier D, Páez R, Reinheimer J, Pot B, Vinderola G, Grangette C. Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice.
Sci. Rep. 7: 43211.

Alard J, Peucelle V, Boutillier D, Breton J, Kuylle S, Pot B, Holowacz S, and Grangette C.. 2017. New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches.
Benef. Microbe. 9 :317.

Ghinnagow R, Cruz LJ. Macho-Fernandez E, Faveeuw C and Trottein F (2017). Enhancement of adjuvant functions of NKT cells using nanovector delivery systems: application in anticancer immune therapy. Front. Immunol. 8:879.

Roquilly A and Trottein F (2017). Influenza and secondary bacterial infections: threats and treatments. Medecine & Science. 33:528.

Ayari A and Wolowczuk I (2017). Physiology and pathophysiology of adipose tissue-derived cytokine networks. Chapter of a book entitled “Cytokine effector functions in tissues” eds. Elsevier.

2016

Barthelemy A, Ivanov S, Fontaine J, Soulard D, Bouabe H, Paget C, Faveeuw,C and Trottein F. Influenza A virus-induced release of interleukin-10 inhibits the antimicrobial activities of invariant natural killer T cells during invasive pneumococcal superinfection.
Muc. Immunol. 10:460.

Le Gars M, Haustant M, Klezovich M, Paget C, Trottein F*, Goossens* PL and Tournier JN* . Mechanisms of invariant Natural Killer T cell activity in restraining Bacillus anthracis systemic dissemination.
J. Immunol. 7:3225.

Alard J, Lehrter V, Rhimi M, Mangin I, Peucelle V, Abraham AL, Mariadassou M, Maguin E, Waligora-Dupriet AJ, Pot B, Wolowczuk I, Grangette C. Beneficial metabolic effects of selected probiotics on diet-induced obesity and insulin resistance in mice are associated with improvement of dysbiotic gut microbiota.
Environ. Microbiol. 18:1484.

Bindels LB, Neyrinck AM, Claus SP, Le Roy CI, Grangette C, Pot B, Martinez I, Walter J, Cani PD, Delzenne NM. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia.
ISME J. 10: 1456

Germain N, Viltart O, Loyens A, Bruchet C, Nadin K, Wolowczuk I, Estour B, Galusca B. Interleukin-7 Plasma Levels in Human Differentiate Anorexia Nervosa, Constitutional Thinness and Healthy Obesity.
PLoS One.11:e0161890.