Y Ganor, A Sennepin, CA Dutertre, F Real, L Prevedel, L Xu, D Tudor, B Charmeteau, A Couedel-Courteille, S Marion, A Zenak, J Jourdain, Z Zhou, A Schmitt, C Capron, EA Eugenin, R Cheynier, M Revol, S Cristofari, A Hosmalin, M Bomsel. Tissue macrophages are major HIV-1 reservoirs in male urethra of patients under suppressive antiretroviral therapy. Accepted in Nature Microbiology.

Bouchut A, Rotili D, Pierrot C, Valente S, Lafitte S, Schultz J, Hoglund U, Mazzone R, Lucidi A, Fabrizi G, Pechalrieu D, Arimondo PB, Skinner-Adams TS, Chua MJ, Andrews KT, Mai A, Khalife J. (2019) Identification of novel quinazoline derivatives as potent antiplasmodial agents. Eur J Med Chem. 161:277-291.



Venugopal K, Marion S. (2018) Secretory organelle trafficking in Toxoplasma gondii: A long story for a short travel. Int J Med Microbiol. 308(7):751-760.

Lenne A, De Witte C, Tellier G, Hollin T, Aliouat EM, Martoriati A, Cailliau K, Saliou JM, Khalife J, Pierrot C. (2018) Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum. Frontiers in Microbiology 9:2617.

Song OR, Queval CJ, Iantomasi R, Delorme V, Marion S, Veyron-Churlet R, Werkmeister E, Popoff M, Ricard I, Jouny S, Deboosere N, Lafont F, Baulard A, Yeramian E, Marsollier L, Hoffmann E, Brodin P. ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton. EMBO Rep. 2018 Jan;19(1):29-42. doi: 10.15252/embr.201744371. Epub 2017 Nov 15.

Pierce RJ and Khalife J. (2018) Parasite Epigenetic Drug Targets. In Jung M. ed. “Epigenetic Drug Discovery”, Wiley (Germany)

Lesage K, Huot L, Mouveaux T, Courjol F, Saliou JM, Gissot M. (2018) Cooperative binding of ApiAP2 transcription factors is crucial for the expression of virulence genes in Toxoplasma gondii. Nucleic Acids Res. 2018 May 21

Fréalle E, Gosset P, Leroy S, Delattre C, Wacrenier A, Zenzmaier C, Zawadzki C, Aliouat EM, Perkhofer S (2018). In vitro coagulation triggers anti-Aspergillus fumigatus neutrophil response. Future Microbiology, 13:659-669.

Aliouat EM, Dei-Cas E., Gantois N, Pottier M, Pinçon C, Hawser S, Lier A, Huang D.B (2018). In Vitro and in Vivo Activity of Iclaprim, a Diaminopyrimidine Compound, a Potential Therapeutic Alternative Against Pneumocystis Pneumonia. European Journal of Clinical Microbiology and Infectious Diseases, 37(3):409-415.

Amman F, D'Halluin A, Antoine R, Huot L, Bibova I, Keidel K, Slupek S, Bouquet P, Coutte L, Caboche S, Locht C, Vecerek B, Hot D. (2018) Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis. RNA Biol. 2018 May 18:1-9

Pierrot C, Zhang X, Zhangi G, Fréville A, Rebollo A, Khalife J. (2018)  Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro. Drug Des Devel Ther.12:85-88.

Courjol F, Gissot M. (2018)  A coiled-coil protein is required for coodination of karyokinesis and cytokinesis in Toxoplasma gondii. Cell Microbiol 10.111/cmi.12832.

Avila AR, Cabezas-Cruz A, Gissot M. (2018)  mRNA export in the apicomplexan parasite Toxoplasma gondii : emerging divergent components of a crucial pathway. Parasit Vectors  11(1): 62.




Cabezas-Cruz, A., Mateos-Hernandez, L., Alberdi, P., Villar, M., Riveau, G., Hermann, E., Schacht, A. M., Khalife, J., Correia-Neves, M., Gortazar, C. and de la Fuente, J. (2017) Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases, Experimental & molecular medicine. 49, e301.

Courjol, F., Mouveaux, T., Lesage, K., Saliou, J. M., Werkmeister, E., Bonabaud, M., Rohmer, M., Slomianny, C., Lafont, F. and Gissot, M. (2017) Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex, Cellular and molecular life sciences. 74, 2107-2125.

Deveuve, Q., Lesage, K., Mouveaux, T. and Gissot, M. (2017) The Toxoplasma gondii inhibitor-2 regulates protein phosphatase 1 activity through multiple motifs, Parasitology research.

Blondiaux, N., Moune, M., Desroses, M., Frita, R., Flipo, M., Mathys, V., Soetaert, K., Kiass, M., Delorme, V., Djaout, K., Trebosc, V., Kemmer, C., Wintjens, R., Wohlkonig, A., Antoine, R., Huot, L., Hot, D., Coscolla, M., Feldmann, J., Gagneux, S., Locht, C., Brodin, P., Gitzinger, M., Deprez, B., Willand, N. & Baulard, A. R. (2017) Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420, Science. 355, 1206-1211.

Frealle, E., Valade, S., Guigue, N., Hamane, S., Chabe, M., Le Gal, S., Damiani, C., Totet, A., Aliouat, E. M., Nevez, G. & Menotti, J. (2017) Diffusion of Pneumocystis jirovecii in the surrounding air of patients with Pneumocystis colonization: frequency and putative risk factors, Medical mycology. 55, 568-572.

Gissot, M., Hovasse, A., Chaloin, L., Schaeffer-Reiss, C., Van Dorsselaer, A. and Tomavo, S. (2017) An evolutionary conserved zinc finger protein is involved in Toxoplasma gondii mRNA nuclear export, Cellular microbiology. 19.

Venugopal, K., Werkmeister, E., Barois, N., Saliou, J. M., Poncet, A., Huot, L., Sindikubwabo, F., Hakimi, M. A., Langsley, G., Lafont, F. and Marion, S. (2017) Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division, PLoS pathogens. 13, e1006331.




Hollin T, De Witte C, Lenne A, Pierrot C, and Khalife J (2016) Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum. BMC genomics 17, 246.

Khalife J, and Pierrot C (2016) Phosphatases are emerging as novel druggable targets in Plasmodium. Future Microbiol. 11:603-6.

Khalife S, Chabe M, Gantois N, Audebert C, Pottier M, Hlais S, Pincon C, Chassat T, Pierrot C, Khalife J, Aliouat-Denis CM, and Aliouat el M (2016) Relationship Between Pneumocystis carinii Burden and the Degree of Host Immunosuppression in an Airborne Transmission Experimental Model. J Eukaryot Microbiol 63, 309-317.

Sauer B, Skinner-Adams TS, Bouchut A, Chua MJ, Pierrot C, Erdmann F, Robaa D, Schmidt M, Khalife J, Andrews KT and Sippl W (2016) Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum. Eur J Med Chem. 23;127:22-40. doi: 10.1016/j.ejmech.2016.12.041

Coutte, L., Huot, L., Antoine, R., Slupek, S., Merkel, T. J., Chen, Q., Stibitz, S., Hot, D. & Locht, C. (2016) The multifaceted RisA regulon of Bordetella pertussis, Scientific reports. 6, 32774.

Druelle, C., Drullion, C., Desle, J., Martin, N., Saas, L., Cormenier, J., Malaquin, N., Huot, L., Slomianny, C., Bouali, F., Vercamer, C., Hot, D., Pourtier, A., Chevet, E., Abbadie, C. & Pluquet, O. (2016) ATF6alpha regulates morphological changes associated with senescence in human fibroblasts, Oncotarget. 7, 67699-67715.

Herate C, Ramdani G, Grant NJ, Marion S, Gasman S, Niedergang F, Benichou S, Bouchet J. Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages. PLoS One. 2016;11:e0145617

Letronne, F., Laumet, G., Ayral, A. M., Chapuis, J., Demiautte, F., Laga, M., Vandenberghe, M. E., Malmanche, N., Leroux, F., Eysert, F., Sottejeau, Y., Chami, L., Flaig, A., Bauer, C., Dourlen, P., Lesaffre, M., Delay, C., Huot, L., Dumont, J., Werkmeister, E., Lafont, F., Mendes, T., Hansmannel, F., Dermaut, B., Deprez, B., Herard, A. S., Dhenain, M., Souedet, N., Pasquier, F., Tulasne, D., Berr, C., Hauw, J. J., Lemoine, Y., Amouyel, P., Mann, D., Deprez, R., Checler, F., Hot, D., Delzescaux, T., Gevaert, K. & Lambert, J. C. (2016) ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease, EBioMedicine. 9, 278-292.

Tellier G, Lenne A, Cailliau Maggio K, Cabezas-Cruz A, Valdés J J, Martoriati A, Aliouat EM, Gosset P, Delaire B, Fréville A, Pierrot C and Khalife J. (2016) Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1. Front. Microbiol




Chalmers IW, Fitzsimmons CM, Brown M, Pierrot C, Jones FM, Wawrzyniak JM, Fernandez-Fuentes N, Tukahebwa EM, Dunne DW, Khalife J, and Hoffmann KF (2015) Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Negl Trop Dis 9, e0003920.

Frealle, E., Gantois, N., Aliouat-Denis, C. M., Leroy, S., Zawadzki, C., Perkhofer, S., Aliouat, E. M. & Dei-Cas, E. (2015) Comparison of different blood compartments for the detection of circulating DNA using a rat model of Pneumocystis pneumonia, Medical mycology. 53, 754-9.

Khalife, S., Aliouat, E. M., Aliouat-Denis, C. M., Gantois, N., Devos, P., Mallat, H., Dei-Cas, E., Dabboussi, F., Hamze, M. & Frealle, E. (2015) First data on Pneumocystis jirovecii colonization in patients with respiratory diseases in North Lebanon, New microbes and new infections. 6, 11-4.

Reimers N, Homann A, Hoschler B, Langhans K, Wilson RA, Pierrot C, Khalife J, Grevelding CG, Chalmers IW, Yazdanbakhsh M, Hoffmann KF, Hokke CH, Haas H, and Schramm G (2015) Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7. PLoS Negl Trop Dis 9, e0003593.



Boulila Y, Tomavo S, Gissot M. (2014) A RGG motif protein is involved in Toxoplasma gondii stress-mediated response. Mol Biochem Parasitol. 196(1):1-8. doi: 10.1016/j.molbiopara.2014.07.009..

Freville A, Tellier G, Vandomme A, Pierrot C, Vicogne J, Cantrelle FX, Martoriati A, Cailliau-Maggio K, Khalife J, and Landrieu I (2014) Identification of a Plasmodium falciparum inhibitor-2 motif involved in the binding and regulation activity of protein phosphatase type 1. FEBS J 281, 4519-4534.

Pandey R, Mohmmed A, Pierrot C, Khalife J, Malhotra P, and Gupta D (2014) Genome wide in silico analysis of Plasmodium falciparum phosphatome. BMC genomics 15, 1024.


Vandomme A, Freville A, Cailliau K, Kalamou H, Bodart JF, Khalife J, and Pierrot C (2014) PhosphoTyrosyl phosphatase activator of Plasmodium falciparum: identification of its residues involved in binding to and activation of PP2A. Int J Mol Sci 15, 2431-2453.




Bettencourt P, Marion S, Pires D, Santos LF, Lastrucci C, Carmo N, Blake J, Benes V, Griffiths G, Neyrolles O, Lugo-Villarino G, Anes E. (2013). Actin-binding protein regulation by microRNAs as a novel microbial strategy to modulate phagocytosis by host cells: the case of N-Wasp and miR-142-3p. Front Cell Infect Microbiol. 3:19

Dubar F, Slomianny C, Khalife J, Dive D, Kalamou H, Guerardel Y, Grellier P, and Biot C (2013) The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition. Angew Chem 52, 7690-7693.

Freville A, Cailliau-Maggio K, Pierrot C, Tellier G, Kalamou H, Lafitte S, Martoriati A, Pierce RJ, Bodart JF, and Khalife J (2013) Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy. BMC Biol 11, 80.

Gissot M, Walker R, Delhaye S, Alayi TD, Huot L, Hot D, Callebaut I, Schaeffer-Reiss C, Dorsselaer AV, Tomavo S. (2013) Toxoplasma gondii Alba proteins are involved in translational control of gene expression. J Mol Biol. 425(8):1287-301. doi: 10.1016/j.jmb.2013.01.039.

Walker R, Gissot M, Huot L, Alayi TD, Hot D, Marot G, Schaeffer-Reiss C, Van Dorsselaer A, Kim K, Tomavo S. (2013) Toxoplasma transcription factor TgAP2XI-5 regulates the expression of genes involved in parasite virulence and host invasion. J Biol Chem. 288(43):31127-38. doi: 10.1074/jbc.M113.486589.

Walker R, Gissot M, Croken MM, Huot L, Hot D, Kim K, Tomavo S. (2013) The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation. Mol Microbiol. 87(3):641-55. doi: 10.1111/mmi.12121.

Khalife J, Fréville A, Vandomme A, Pierrot C (2013) Phosphatases. Encyclopedia of Malaria. (ed. M hommel and PG Kremsner) Springer Science New York. DOI 10.1007/978-1-4614-8757-9_59-1.




Biot C, Dubar F, Khalife J, and Slomianny C (2012) Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes. Metallomics 4, 780-783.

Dubar F, Bohic S, Dive D, Guerardel Y, Cloetens P, Khalife J, and Biot C (2012) Deciphering the Resistance-Counteracting Functions of Ferroquine in Plasmodium falciparum-Infected Erythrocytes. ACS Med Chem Lett 3, 480-483.

Dubar F, Bohic S, Slomianny C, Morin JC, Thomas P, Kalamou H, Guerardel Y, Cloetens P, Khalife J, and Biot C (2012) In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes. Chem Commun 48, 910-912.

Fitzsimmons CM, Jones FM, Pinot de Moira A, Protasio AV, Khalife J, Dickinson HA, Tukahebwa EM, and Dunne DW (2012) Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis? Infect Immunity 80, 4264-4270.

Freville A, Landrieu I, Garcia-Gimeno MA, Vicogne J, Montbarbon M, Bertin B, Verger A, Kalamou H, Sanz P, Werkmeister E, Pierrot C, and Khalife J (2012) Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival. J Biol Chem 287, 1306-1321.

Gissot M, Walker R, Delhaye S, Huot L, Hot D, Tomavo S. (2012) Toxoplasma gondii chromodomain protein 1 binds to heterochromatin and colocalises with centromeres and telomeres at the nuclear periphery. PLoS One. 7(3):e32671. doi: 10.1371/journal.pone.0032671.

Khalife J (2012) Current strategies for drug development against major human parasites: malaria and schistosomiasis. Curr Pharm Des 18, 3453.

Marion S., J. Mazzolini, F. Herit, P. Bourdoncle, N. Kambou-Pene, S. Hailfinger, M. Sachse, A. Benmerah, A. Echard, M. Thome and F. Niedergang. (2012). The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles. Developmental Cell. 23(5):954-67.

Pierrot C, Freville A, Olivier C, Souplet V, and Khalife J (2012) Inhibition of protein-protein interactions in Plasmodium falciparum: future drug targets. Curr Pharm Des 18, 3522-3530.




Biot C, Nosten F, Fraisse L, Ter-Minassian D, Khalife J, and Dive D (2011) The antimalarial ferroquine: from bench to clinic. Parasite 18, 207-214.

Brooks CF, Francia ME, Gissot M, Croken MM, Kim K, Striepen B. (2011) Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle. Proc Natl Acad Sci U S A. 108(9):3767-72. doi: 10.1073/pnas.1006741108.

Dubar F, Egan TJ, Pradines B, Kuter D, Ncokazi KK, Forge D, Paul JF, Pierrot C, Kalamou H, Khalife J, Buisine E, Rogier C, Vezin H, Forfar I, Slomianny C, Trivelli X, Kapishnikov S, Leiserowitz L, Dive D, and Biot C (2011) The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance. ACS chemical biology 6, 275-287.

Marion S., Hoffmann E., Holzer D., Le Clainche C., Martin M., Sachse M., Ganeva I., Mangeat P. and G. Griffiths (2011) Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion. Traffic 12:421-37.

Pierrot C, Acroute dit Vampouille A, Vandomme A, Lafitte S, Pierce RJ, Hot D, and Khalife J (2011) Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection. Cell Microbiol 13, 752-763.



Acroute dit Vampouille A, Lafitte S, Dive D, Khalife J, and Pierrot C (2010) A role for CD4+ and CD8+ cells and not for CD25+ cells in the control of Plasmodium berghei Anka blood stage parasites in rats. Parasite 17, 53-60

Daher W, Pierrot C, Kalamou H, Pinder JC, Margos G, Dive D, Franke-Fayard B, Janse CJ, and Khalife J (2010) Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development. J Biol Chem 285, 20180-20191

Hoffmann E., Marion S., Mishra B.B., Kratzke R., Ahmad F., John M., Holzer D., Anand P.K., Weiss D.G., Griffiths G. and Kuznetsov S.A. (2010) The phagocytic receptor programs gene expression and phagosome functions in macrophages. Eur. J. Cell Biology 89:693-704.