current PhDs - Post-Docs


 

current PhD Students

 

 

Salam El Ashkar (2016-2019) Joint PhD between Université du Liban and Université de Lille
Fellowship:    Lebanese fellowship
Title:    Transmission and antimicrobial resistance of tuberculosis in resident and displaced populations in Lebanon by Next Generation Sequencing”
Supervisor:    P. Supply


Alex Rivera (2016-2019), Université de Lille II
Fellowship:    University of Lille/Region Hauts de France
Title:    Copper homeostasis in Bordetella pertussis and its relationship with virulence
Supervisor:    F. Jacob-Dubuisson


Gauthier Roy
(2018-2021)  Université de Lille
Fellowship:    Université de Lille
Title: Characterization of a new copper transport system in B; pertussis: mode of action and regulation
Supervisor: F. Jacob-Dubuisson


Anaïs Thiriard
(2017-2019), Université de Lille
Fellowship:    Inserm/Région Haut de France
Title:    Study on the functionality of anti-pertussis antibodies
Supervisor:    Camille Locht

 

current Post-Docs

 

 

Thomas Belcher (UK), since 2017
Financial supports: CPER CTRL IPL

Kamel Djaout (Algeria), 2016 - ongoing
Financial supports: Industrial partnership (Bioversys-GSK)
Publications:
-    Blondiaux N, Moune M, (…), Djaout K, (…), Baulard AR (2017) Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science 355:1206-1211.


Rosangela-Maria Frita (Portugal), 2015 - ongoing
Financial supports: ANR Tea-4-Two
Publications:
-    Rens C, Laval F, Daffé M, Denis O, Frita R, Baulard A, Wattiez R, Lefèvre P, Fontaine V (2016) Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria. Antimicrob Agents Chemother 60:6193-9.
-    Blondiaux N, Moune M, Desroses M, Frita R, (…), Djaout K, (…), Baulard AR (2017) Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science 355:1206-1211.
-    Tatum NJ, Liebeschuetz JW, Cole JC, Frita R, Herledan A, Baulard AR, Willand N, Pohl E (2017) New active leads for tuberculosis booster drugs by structure-based drug discovery. Org Biomol Chem 15:10245-10255.


Romain Veyron-Churlet (France), 2015 - ongoing
Financial supports: Horizon2020 TBVAC2020
Publications:
-    Veyron-Churlet R, Dupres V, Saliou JM, Lafont F, Raze D, Locht C (2018) Rv0613c/MSMEG_1285 interacts with HBHA and mediates its proper cell-surface exposure in mycobacteria. Int J Mol Sci. In press.


former PhDs - Post Docs


 

Former PhD Students

 

 

Elian Dupré (2009-2013), Université de Lille II
Fellowship:  French Research Ministry for 3 years and FRM for the 4th
Title: Virulence regulation in Bordetella pertussis : BvgS, an original model for a two-component system receptor
Supervisor:  F. Jacob-Dubuisson
Current employment: post-doctoral fellow, University of Lille 1


Jérémy Guérin (2011-2014), Université de Lille II
Fellowship:  Institut Pasteur of Lille/ Région Nord-Pas de Calais.
Title: Conformationnal dynamics of FhaC, the transporter across the outer membrane of the filamentous hemaggutinin in Bordetella pertussis
Supervisor:  F. Jacob-Dubuisson
Current employment: post-doctoral fellow, NIH, USA


Elodie Lesne (2013-2016), Université de Lille II
Fellowship:  INSERM/ Région Nord-Pas de Calais.
Title:  Virulence regulation by the whooping cough agent Bordetella pertussis : signaling by the sensor-kinase BvgS
Supervisor:  F. Jacob-Dubuisson
Current employment: scientist at Public Health England, Porton Down, Salisbury, UK


Marion Prieri
(2015-2018), Université de Lille
Fellowship:    Institut Pasteur de Lille/ Région Haut de France
Title: Reprogramming the anti-TB pro-drugs: design, development and biological evaluation of inhibitors of transcriptional regulators
Co-SupervisorS:    Alain Baulard / Nicolas Willand
Current employment: Newcastle University, Newcastle-upon-Tyne, UK

 

Former Post-Docs

 

 

 

Catherine Baud (France), from 2010 to 2014
Financial support: ANR grant DYN FHAC
Publications:
-    Baud C, Guérin J, Petit E, Lesne E, Dupré E, Locht C, Jacob-Dubuisson F (2014) Translocation path of a substrate protein through its Omp85 transporter. Nat Commun 5: 5271.
-    Guérin J, Baud C, Touati N, Saint N, Willery E, Locht C, Vezin H, Jacob-Dubuisson F (2014) Conformational dynamics of protein transporter FhaC: large-scale motions of plug helix. Mol Microbiol 92: 1164-1176.


Elian Dupré (France), from 2013 to 2016
Financial support: ANR grant MECA VENUS
Publications:
-    Dupre E, Herrou J, Lensink MF, Wintjens R, Vagin A, Lebedev A, Crosson S, Villeret V, Locht C, Antoine R, Jacob-Dubuisson F (2015) Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS. PLoS Pathog 11: e1004700.
-    Dupre E, Lesne E, Guerin J, Lensink MF, Verger A, de Ruyck J, Brysbaert G, Vezin H, Locht C, Antoine R, Jacob-Dubuisson F (2015) Signal transduction by BvgS sensor kinase. Binding of modulator nicotinate affects the conformation and dynamics of the entire periplasmic moiety. J Biol Chem 290: 26473.


Jeremy Guerin
(France), 2015
Financial support: ANR grant DYN FHAC
Publication:
-    Guerin J, Saint N, Baud C, Meli AC, Etienne E, Locht C, Vezin H, Jacob-Dubuisson F (2015) Dynamic interplay of membrane-proximal POTRA domain and conserved loop L6 in Omp85 transporter FhaC.  Mol Microbiol 98: 490-501.


Hannah Kammoun (Tunisia), oct. 2012 to Dec. 2013
Financial support: FP7 NewTBVac
Publication:
-    Feunou PF, Kammoun H, Debrie AS, Locht C (2014) Heterologous prime-boost immunization with live attenuated B. pertussis BPZE1 followed by acellular pertussis vaccine in mice. Vaccine 32:4281428-8.


Raphaella Iantomasi 2015-2016
Financial support: Lille European Metropolitan (MEL)
Publication:
-    Iantomasi et al (in preparation) Low virulence of Mycobacterium canettii strains in cellular infection models


Martin Moune
(Cameroon/France), from 2014 to 2017;
Financial supports: PRIM (2014-2016) and GSK-Bioversys industrial partnership (2016-2018)
Publications:
-    Blondiaux N, Moune M*, (…), Baulard AR (2017) Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science 355:1206-1211. *Co-first author
-    Wohlkönig A, Remaut H, Moune M, Tanina A, Meyer F, Desroses M, Steyaert J, Willand N, Baulard AR, Wintjens R (2017) Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2. Biochem Biophys Res Commun 487:403-408.


Luis Solans (Spain), from 2015 to January 31st, 2018
Financial supports: ILIAD Biotechnologies (industrial support)
Publications:
-    Rivera-Millot A, Lesne E, Solans L, Coutte L, Bertrand-Michel J, Froguel P, Dhennin V, Hot D, Locht C, Antoine R, Jacob-Dubuisson F (2017) Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis. PLoS One 12:e0176396
-    Hovingh ES, Mariman R, Solans L, Hijdra D, Hamstra HJ, Jongerius I, van Gent M, Mooi F, Locht C, Pinelli E (2018) Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor. Emerg Microbes Infect 7:39.