Assistant-e Ingénieur-e / Technicien-ne
CDD 1 an dans le cadre d’un projet START-AIRR soutenu par la région Haut de France.
Au sein de l’équipe de Biologie des Apicomplexes Parasites du Centre d’infection et d’immunité de Lille (CNRS UMR9017, INSERM U1019) située sur le campus de l’Institut Pasteur de Lille, vous participerez à la recherche de nouvelles drogues qui seraient actives contre la forme aigue et latente de la toxoplasmose. Vous appliquerez les protocoles déjà établis pour mesurer l’activité des drogues sélectionnées mais aussi participerez au développement de nouvelles méthodologies permettant de mieux appréhender les effets de ces drogues sur le parasite Toxoplasma gondii. En coordination avec un Ingénieur de l’équipe vous participerez aux tests de ces composés autant in vitro que in vivo. Vous avez des compétences pratiques et théoriques en culture cellulaire et biologie moléculaire. Vous êtes motivé-e-s par le développement de nouvelles techniques.
Poste à pourvoir à l’automne 2020.
Merci d’envoyer votre candidature (CV et lettre de motivation) à : Mathieu GISSOT
The "Lung Infection and Innate Immunity" laboratory is mainly interested in two clinically relevant pathogens: influenza A virus and Streptococcus pneumoniae. Our objectives are (i) to define host molecular and cellular factors that predispose to bacterial infections in the context of pulmonary inflammation (such as during flu) and metabolic disorders and (ii) to develop new strategies to strengthen host defense mechanisms against respiratory pathogens.
To reinforce our research activities, we aim to welcome a young scientist with the potential to be recruited as a permanent scientist in our team and to bring complementary expertise. A minimal 3-year postdoc is required. Interested applicants can send a letter explaining why they are interested and their curriculum vitae by email.
3-years postdoctoral fellowship in the CIIL-Team OpInfIELD.
Starting in September 2020 at Pasteur Institute (Lille- France)
Description of the Topic:
Lung inflammatory disorders such as chronic obstructive pulmonary disease (COPD) are associated with an increased susceptibility to respiratory infections which trigger episodes of exacerbation, a phenomenon that is clinically of increasing importance. Nevertheless, COPD is a multifactorial disease involving environmental, genetic and epigenetic factors. This is probably a key factor explaining that less than 30% smokers develop the disease. Indeed, physiopathologic mechanisms of COPD are still poorly understood and particularly, little is known about gene–environment interactions. We identified a genetic polymorphism (α5SNP) present on nicotinic acetylcholine receptor (nAChR) that might directly contribute to COPD pathology, sensitizing the lung to oxidative stress action, and altering lung defense mechanisms.
In this context, the overall goal of this proposal is to demonstrate that α5SNP is involved in COPD development and progression (through exacerbation episodes) and secondary that α5SNP signaling modulation might be used as a personalized therapeutic solution. For this, we will analyze a) the association between α5SNP expression and COPD clinical phenotype in patients, b) physiopathologic mechanisms by which α5SNP interferes with COPD and AE-COPD in murine models, c) its modulation by new drug. The recruited person will evaluate the impact of α5SNP on the immune system and particularly on antigen-presenting cells.
The candidate should have a PhD and the desire to undertake a first or second post-doctoral fellowship. You should already have a validated experience in experimental models (animal experimentation accreditation is required) and in immunology. Some knowledge about the mechanisms involved in lung inflammation and infectious diseases will be appreciated.
This project implicating the collaboration of 3 french teams, a good ability of the candidate to interact with the members of our team and with our collaborators is required. We seek autonomous, enthusiastic and energetic people with strong teamwork skills.
At the end of this project, the postdoctorant should have demonstrated the association between α5SNP expression and a COPD clinical phenotype in patients, a new physiopathologic mechanisms by which α5SNP interferes with COPD and AE-COPD in murine models and the interest to develop personalized medicine for the patients having this SNP.
The chemical biology of antibiotics team (CBA), is looking for a postdoctoral candidate (PhD essential), who is willing to do short term postdoctoral research project (8-9 months). This candidate will help in the genetic engineering of rare actinomycete strains to force the production of “silent antibiotics”, and to aid in the purification of an enoyl reductase from E.coli. Work will support ongoing research programs that have already substantial preliminary data.
The candidate should have experience in microbiology, genetic engineering, cloning, conjugation, recombinant protein production. Experience in chemical biology is a bonus. Candidate should be happy to work in close collaboration with other members of the group. Spoken and written English is a bonus.
Candidates should contact the CBA team head, Ruben Hartkoorn by email, with a letter of motivation and a CV. The start date for this postdoctoral position is as soon as possible.
Starting date: May-June 2018
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