Publications


Lesne E, Coutte L, Solans L, Slupek S, Debrie AS, Dhennin V, Froguel P, Hot D, Locht C, Antoine R, Jacob-Dubuisson F. Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS. PLoS One. 2018 Oct 11;13(10):e0204861. doi: 10.1371/journal.pone.0204861. eCollection 2018. PubMed PMID: 30307950.

Keidel K, Amman F, Bibova I, Drzmisek J, Benes V, Hot D, Vecerek B. Signal transduction-dependent small regulatory RNA is involved in glutamate metabolism of the human pathogen Bordetella pertussis. RNA. 2018 Aug 10. pii: rna.067306.118. doi: 10.1261/rna.067306.118. [Epub ahead of print] PubMed PMID: 30097543.

Vignal C, Djouina M, Pichavant M, Caboche S, Waxin C, Beury D, Hot D, Gower Rousseau C, Body-Malapel M. Chronic ingestion of deoxynivalenol at human dietary levels impairs intestinal homeostasis and gut microbiota in mice. Arch Toxicol. 2018 Jul;92(7):2327-2338. doi: 10.1007/s00204-018-2228-6. Epub 2018 May 26. PubMed PMID: 29804187.

Amman F*, D'Halluin A*, Antoine R, Huot L, Bibova I, Keidel K, Slupek S, Bouquet P, Coutte L, Caboche S, Locht C, Vecerek B, Hot D. Primary transcriptome analysis reveals importance of IS elements for the shaping of the transcriptional landscape of Bordetella pertussis. RNA Biol. 2018 May 18:1-9. doi: 10.1080/15476286.2018.1462655. [Epub ahead of print] PubMed PMID: 29683387.
*: co-first authors

Audebert C, Hot D, Caboche S. [Prospects for applications in human health of nanopore-based sequencing]. Med Sci (Paris). 2018 Apr;34(4):319-325. doi: 10.1051/medsci/20183404012. Epub 2018 Apr 16. French. PubMed PMID: 29658474.

Caboche S, Even G, Loywick A, Audebert C, Hot D. MICRA: an automatic pipeline for fast characterization of microbial genomes from high-throughput sequencing data. Genome Biol. 2017 Dec 19;18(1):233. doi: 10.1186/s13059-017-1367-z. PubMed PMID: 29258574; PubMed Central PMCID: PMC5738152.

Siegwald L, Audebert C, Even G, Viscogliosi E, Caboche S, Chabé M. Targeted metagenomic sequencing data of human gut microbiota associated with Blastocystis colonization. Sci Data. 2017 Jun 27; 4: 170081. doi: 10.1038/sdata.2017.81. PubMed PMID: 28654083; PubMed Central PMCID: PMC5486356.

Rivera-Millot A, Lesne E, Solans L, Coutte L, Bertrand-Michel J, Froguel P, Dhennin V, Hot D, Locht C, Antoine R, Jacob-Dubuisson F. Characterization of a Bvg-regulated fatty acid methyl-transferase in Bordetella pertussis. PLoS One. 2017 May 11;12(5):e0176396. doi: 10.1371/journal.pone.0176396. eCollection 2017. PubMed PMID: 28493897; PubMed Central PMCID: PMC5426589.

Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkönig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Déprez B, Willand N, Baulard AR. Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. Science. 2017 Mar 17; 355(6330):1206-1211. doi: 10.1126/science.aag1006. PubMed PMID: 28302858.

Siegwald L, Touzet H, Lemoine Y, Hot D, Audebert C, Caboche S. Assessment of Common and Emerging Bioinformatics Pipelines for Targeted Metagenomics. PLoS One. 2017 Jan 4; 12(1):e0169563. doi: 10.1371/journal.pone.0169563. PubMed PMID: 28052134; PubMed Central PMCID: PMC5215245.

Coutte L, Huot L, Antoine R, Slupek S, Merkel TJ, Chen Q, Stibitz S, Hot D, Locht C. The multifaceted RisA regulon of Bordetella pertussis. Sci Rep. 2016 Sep 13; 6: 32774. doi: 10.1038/srep32774. PubMed PMID: 27620673; PubMed Central PMCID: PMC5020355.

Druelle C, Drullion C, Deslé J, Martin N, Saas L, Cormenier J, Malaquin N, Huot L, Slomianny C, Bouali F, Vercamer C, Hot D, Pourtier A, Chevet E, Abbadie C, Pluquet O. ATF6a regulates morphological changes associated with senescence in human fibroblasts. Oncotarget. 2016 Aug 22. doi: 10.18632/oncotarget.11505. [Epub ahead of print] PubMed PMID: 27563820.

Letronne F, Laumet G, Ayral AM, Chapuis J, Demiautte F, Laga M, Vandenberghe ME, Malmanche N, Leroux F, Eysert F, Sottejeau Y, Chami L, Flaig A, Bauer C, Dourlen P, Lesaffre M, Delay C, Huot L, Dumont J, Werkmeister E, Lafont F, Mendes T, Hansmannel F, Dermaut B, Deprez B, Hérard AS, Dhenain M, Souedet N, Pasquier F, Tulasne D, Berr C, Hauw JJ, Lemoine Y, Amouyel P, Mann D, Déprez R, Checler F, Hot D, Delzescaux T, Gevaert K, Lambert JC. ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease. EBioMedicine. 2016 Jul; 9: 278-92. doi: 0.1016/j.ebiom.2016.06.002. Epub 2016 Jun 2. PubMed PMID: 27333034; PubMed Central PMCID: PMC4972530.

Fougeron D, Van Maele L, Songhet P, Cayet D, Hot D, Van Rooijen N, Mollenkopf HJ, Hardt WD, Benecke AG, Sirard JC. Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract. Vaccine. 2015 May 20. pii: S0264-410X(15)00654-4. doi: 10.1016/j.vaccine.2015.05.022. [Epub ahead of print] PubMed PMID: 26003491.

Spear R, Boytard L, Blervaque R, Chwastyniak M, Hot D, Vanhoutte J, Staels B, Lemoine Y, Lamblin N, Pruvot FR, Haulon S, Amouyel P, Pinet F. Adventitial Tertiary Lymphoid Organs as Potential Source of MicroRNA Biomarkers for Abdominal Aortic Aneurysm. Int J Mol Sci. 2015 May 18; 16(5):11276-93. doi: 10.3390/ijms160511276. PubMed PMID: 25993295.

Reinhard A, Bressenot A, Dassonneville R, Loywick A, Hot D, Audebert C, Marchal S, Guillemin F, Chamaillard M, Peyrin-Biroulet L, Bezdetnaya L. Photodynamic Therapy Relieves Colitis and Prevents Colitis-associated Carcinogenesis in Mice. Inflamm Bowel Dis. 2015 May; 21(5):985-95. doi: 10.1097/MIB.0000000000000354. PubMed PMID: 25806846.

Hot D*, Bibova I*, Keidel K, Amman F, Slupek S, Cerny O, Gross R, Vecerek B. Transcriptional profiling of Bordetella pertussis reveals requirement of RNA chaperone Hfq for Type III secretion system functionality. RNA Biol. 2015; 12(2):175-85. [Epub ahead of print] PubMed PMID: 25674816.0.
*: co-first authors

Audebert C, Hot D, Lemoine Y et Caboche S. Le séquençage haut-débit : vers un diagnostic basé sur la séquence complète du génome de l’agent infectieux, Médecine/Sciences 2014, 30 : 1144-1151.

Hoo R, Lam JH, Huot L, Pant A, Li R, Hot D, Alonso S. Evidence for a role of the polysaccharide capsule transport proteins in pertussis pathogenesis. PLoS One. 2014 Dec 12; 9(12):e115243. doi: 10.1371/journal.pone.0115243. eCollection 2014. PubMed PMID: 25501560; PubMed Central PMCID: PMC4264864.

Caboche S. Biosynthesis: Bioinformatics bolster a renaissance. Nat Chem Biol. 2014 Sep 17; 10(10):798-800. doi: 10.1038/nchembio.1634. PubMed PMID: 25229448.

Caboche S, Audebert C, Lemoine Y, Hot D. Comparison of mapping algorithms used in high-throughput sequencing: application to Ion Torrent data. BMC Genomics. 2014 Apr 5; 15(1):264. doi: 10.1186/1471-2164-15-264. PubMed PMID: 24708189; PubMed Central PMCID: PMC4051166.

Caboche S, Audebert C, Hot D. High-throughput sequencing, a versatile weapon to support genome-based diagnosis in infectious diseases: applications to clinical bacteriology. Pathogens. 2014, 3(2), 258-279; doi: 10.3390/pathogens3020258

Benamrouz S, Conseil V, Chabe M, Praet M, Audebert C, Blervaque R, Guyot K, Gazzola S, Mouray A, Chassat T, Delaire B, Goetinck N, Gantois N, Osman M, Slomianny C, Dehennaut V, Lefebvre T, Viscogliosi E, Cuvelier C, Dei-Cas E, Creusy C, Certad G. Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and WNT signaling in a rodent model. Dis Model Mech. 2014 Mar 20. [Epub ahead of print] PubMed PMID: 24652769.

Mutez E, Nkiliza A, Belarbi K, de Broucker A, Vanbesien-Mailliot C, Bleuse S, Duflot A, Comptdaer T, Semaille P, Blervaque R, Hot D, Leprêtre F, Figeac M, Destée A, Chartier Harlin MC. Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease. Neurobiol Dis. 2014 Mar; 63:165-70. doi: 10.1016/j.nbd.2013.11.007. Epub 2013 Nov 20. PubMed PMID: 24269915.

Van Maele L, Fougeron D, Janot L, Didierlaurent A, Cayet D, Tabareau J, Rumbo M, Corvo-Chamaillard S, Boulenouar S, Jeffs S, Vande Walle L, Lamkanfi M, Lemoine Y, Erard F, Hot D, Hussell T, Ryffel B, Benecke AG, Sirard JC. Airway structural cells regulate TLR5-mediated mucosal adjuvant activity. Mucosal Immunol. 2013 Sep 25. doi: 10.1038/mi.2013.66. [Epub ahead of print] PubMed PMID: 24064672.

Walker R, Gissot M, Huot L, Alayi TD, Hot D, Marot G, Schaeffer-Reiss C, Van Dorsselaer A, Kim K, Tomavo S. Toxoplasma Transcription Factor TgAP2XI-5 Regulates the Expression of Genes Involved in Parasite Virulence and Host Invasion. J Biol Chem. 2013 Oct 25; 288(43):31127-38. doi: 10.1074/jbc.M113.486589. Epub 2013 Sep 10. PubMed PMID: 24025328.

Bibova I, Skopova K, Masin J, Cerny O, Hot D, Sebo P, Vecerek B. The RNA chaperone Hfq is required for virulence of Bordetella pertussis. Infect Immun. 2013 Nov; 81(11):4081-90. doi: 10.1128/IAI.00345-13. Epub 2013 Aug 26. Erratum in: Infect Immun. 2014 Jul; 82(7):3087. PubMed PMID: 23980112; PubMed Central PMCID: PMC3811842.

Tian TV, Tomavo N, Huot L, Flourens A, Bonnelye E, Flajollet S, Hot D, Leroy X, de Launoit Y, Duterque-Coquillaud M. Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2. Oncogene. 2013 May 27. doi: 10.1038/onc.2013.176. [Epub ahead of print] PubMed PMID: 23708657.

Gissot M, Walker R, Delhaye S, Alayi TD, Huot L, Hot D, Callebaut I, Schaeffer-Reiss C, Dorsselaer AV, Tomavo S. Toxoplasma gondii Alba Proteins Are Involved in Translational Control of Gene Expression. J Mol Biol. 2013 Feb 21. doi:pii: S0022-2836(13)00103-4. 10.1016/j.jmb.2013.01.039. [Epub ahead of print] PubMed PMID: 23454356.

Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P, Chamaillard M. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 2013 Jan 2. doi:pii: 62236. 10.1172/JCI62236. [Epub ahead of print] PubMed PMID: 23281400.

Fréalle E, Aliouat-Denis CM, Delhaes L, Hot D, Dei-Cas E. Transcriptomic Insights into the Oxidative Response of Stress-Exposed Aspergillus Fumigatus. Curr Pharm Des. 2012 Dec 26. [Epub ahead of print] PubMed PMID: 23278536.

Walker R, Gissot M, Croken MM, Huot L, Hot D, Kim K, Tomavo S. The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation. Mol Microbiol. 2012 Dec 14. doi: 10.1111/mmi.12121. [Epub ahead of print] PubMed PMID: 23240624.

Flajollet S, Tian TV, Huot L, Tomavo N, Flourens A, Holder-Espinasse M, Le Jeune M, Dumont P, Hot D, Mallein-Gerin F, Duterque-Coquillaud M. Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative erg transgenic mice. PLoS One. 2012; 7(11):e48656. doi: 10.1371/journal.pone.0048656. Epub 2012 Nov 14. PubMed PMID: 23155398; PubMed Central PMCID: PMC3498236.

Lucau-Danila A, Toitot C, Goulas E, Blervacq AS, Hot D, Bahrman N, Sellier H, Lejeune-Hénaut I, Delbreil B. Transcriptome analysis in pea allows to distinguish chilling and acclimation mechanisms. Plant Physiol Biochem. 2012 Sep; 58:236-44. doi: 10.1016/j.plaphy.2012.07.012. Epub 2012 Jul 20. PubMed PMID: 22858528.

Elass-Rochard E, Rombouts Y, Coddeville B, Maes E, Blervaque R, Hot D, Kremer L, Guérardel Y. Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum. J Biol Chem. 2012 Oct 5; 287(41):34432-44. doi: 10.1074/jbc.M112.378083. Epub 2012 Jul 13. PubMed PMID: 22798072; PubMed Central PMCID: PMC3464548.

Bougault C, Aubert-Foucher E, Paumier A, Perrier-Groult E, Huot L, Hot D, Duterque-Coquillaud M, Mallein-Gerin F. Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes. PLoSOne. 2012; 7(5):e36964. Epub 2012 May 17. PubMed PMID: 22615857; PubMed Central PMCID: PMC3355169.

Gissot M, Walker R, Delhaye S, Huot L, Hot D, Tomavo S. Toxoplasma gondii chromodomain protein 1 binds to heterochromatin and colocalises with centromeres and telomeres at the nuclear periphery. PLoS One. 2012; 7(3):e32671. Epub 2012 Mar 9. PubMed PMID: 22427862; PubMed Central PMCID: PMC3302879.

Normand S, Delanoye-Crespin A, Bressenot A, Huot L, Grandjean T, Peyrin-Biroulet L, Lemoine Y, Hot D, Chamaillard M. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9601-6. Epub 2011 May 18. PubMed PMID: 21593405; PubMed Central PMCID: PMC3111299.

Hot D, Slupek S, Wulbrecht B, D'Hondt A, Hubans C, Antoine R, Locht C, Lemoine Y. Detection of small RNAs in Bordetella pertussis and identification of a novel repeated genetic element. BMC Genomics. 2011 Apr 27; 12:207. PubMed PMID: 21524285; PubMed Central PMCID: PMC3110155.

Pierrot C, Acroute Dit Vampouille A, Vandomme A, Lafitte S, Pierce RJ, Hot D, Khalife J. Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection. Cell Microbiol. 2011 May; 13(5):752-63. doi:10.1111/j.1462-5822.2011.01574.x. [Epub ahead of print] PubMed PMID: 21323829.

Lucau-Danila A, Laborde L, Legrand S, Huot L, Hot D, Lemoine Y, Hilbert JL, Hawkins S, Quillet MC, Hendriks T, Blervacq AS. Identification of novel genes potentially involved in somatic embryogenesis in chicory (Cichorium intybus L.). BMC Plant Biol. 2010 Jun 22; 10:122. PubMed PMID: 20565992.

Lamblin N, Ratajczak P, Hot D, Dubois E, Chwastyniak M, Beseme O, Drobecq H, Lemoine Y, Koussa M, Amouyel P, Pinet F. Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic, and antibody protein array study. J Proteome Res. 2010 Jul 2; 9(7):3720-9. PubMed PMID: 20513153.